Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09907-MazE
Location 2165406..2166007 Replicon chromosome
Accession NZ_CP018180
Organism Liquorilactobacillus nagelii strain TMW 1.1827

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag BSQ50_RS10470 Protein ID WP_148127158.1
Coordinates 2165406..2165750 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag BSQ50_RS10475 Protein ID WP_148127159.1
Coordinates 2165744..2166007 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSQ50_RS10430 2161876..2162067 + 192 WP_057885176.1 DUF2992 family protein -
BSQ50_RS10435 2162096..2162507 - 412 Protein_2015 DNA recombinase -
BSQ50_RS10440 2162722..2163003 + 282 WP_057885175.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
BSQ50_RS10445 2163000..2163356 + 357 WP_057885174.1 type II toxin-antitoxin system YafQ family toxin -
BSQ50_RS12460 2163611..2163784 - 174 WP_187343742.1 hypothetical protein -
BSQ50_RS10450 2163837..2164154 - 318 WP_148127157.1 hypothetical protein -
BSQ50_RS12465 2164404..2164592 - 189 WP_187343796.1 hypothetical protein -
BSQ50_RS10470 2165406..2165750 - 345 WP_148127158.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BSQ50_RS10475 2165744..2166007 - 264 WP_148127159.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BSQ50_RS10480 2166899..2167678 - 780 WP_148127160.1 DUF4931 domain-containing protein -
BSQ50_RS10485 2167992..2169164 + 1173 WP_083478471.1 divalent metal cation transporter -
BSQ50_RS10490 2169602..2170066 - 465 WP_187343793.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
BSQ50_RS10495 2170117..2170881 - 765 WP_148127162.1 nicotinamide riboside transporter PnuC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-101)

Antitoxin

SpoVT-AbrB domain

(12-55)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13011.77 Da        Isoelectric Point: 4.6485

>T68871 WP_148127158.1 NZ_CP018180:c2165750-2165406 [Liquorilactobacillus nagelii]
MVSQGDIFYVNFNLSRGHEQMNRRPAIALSNDLVCQTGNMMIVAPISSTERNFPLYHQLTSSQTVYGKVLLDQTIALDLR
ARHVTDEAIVDHVSREELEEIITLYKLLFSIDDE

Download         Length: 345 bp

>T68871 NZ_CP018180:c2165750-2165406 [Liquorilactobacillus nagelii]
ATGGTAAGCCAAGGTGATATATTTTATGTTAACTTTAATCTGAGTCGTGGTCATGAACAGATGAATAGGCGGCCGGCCAT
TGCTCTAAGCAATGATCTAGTCTGTCAGACAGGTAACATGATGATTGTGGCGCCGATTAGCAGCACCGAGCGTAATTTTC
CGCTATATCATCAACTAACTAGTAGTCAAACAGTCTATGGGAAAGTATTATTAGATCAAACAATAGCCTTAGATTTGCGG
GCAAGACATGTGACTGACGAAGCTATTGTCGATCATGTATCGCGTGAAGAATTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTCAGTATTGATGATGAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10154.51 Da        Isoelectric Point: 7.2049

>AT68871 WP_148127159.1 NZ_CP018180:c2166007-2165744 [Liquorilactobacillus nagelii]
MERIKEQTRLAKWGNSKAARIPSQIIKQLKLDDKQDMTVTIENGSIVLTPIKKNPANIHELFKDWQDDGKRDHELDWGKS
EGNELQW

Download         Length: 264 bp

>AT68871 NZ_CP018180:c2166007-2165744 [Liquorilactobacillus nagelii]
ATGGAACGTATTAAAGAACAAACACGCCTGGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAAACAAGATATGACAGTAACAATTGAAAATGGATCGATTGTTTTAACACCAATAAAAAAGA
ATCCAGCCAATATTCATGAACTATTCAAGGACTGGCAAGATGACGGAAAACGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References