Detailed information of TA system TA068870

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1200646..1201175
• Replicon: chromosome
• Accession: NZ_CP018175
• Organism: Corynebacterium glutamicum strain XV

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: BSP99_RS05755
• Protein ID: WP_075348157.1
• Coordinates: 1200876..1201175 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1B4WJV4
• Locus tag: BSP99_RS05750
• Protein ID: WP_060564305.1
• Coordinates: 1200646..1200879 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BSP99_RS05730	1196691..1197914	-	1224	WP_004568082.1	esterase family protein	-
BSP99_RS05735	1198110..1199195	+	1086	WP_004568081.1	redox-regulated ATPase YchF	-
BSP99_RS05740	1199360..1199605	+	246	WP_060564304.1	hypothetical protein	-
BSP99_RS05745	1199939..1200379	+	441	WP_075348156.1	YtoQ family protein	-
BSP99_RS05750	1200646..1200879	+	234	WP_060564305.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
BSP99_RS05755	1200876..1201175	+	300	WP_075348157.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BSP99_RS05760	1201214..1201480	+	267	WP_087061857.1	helix-turn-helix transcriptional regulator	-
BSP99_RS05765	1201698..1202171	-	474	WP_081302985.1	SAP domain-containing protein	-
BSP99_RS05770	1202337..1202849	-	513	WP_146144404.1	hypothetical protein	-
BSP99_RS05775	1203069..1203527	+	459	WP_060564309.1	NUDIX domain-containing protein	-
BSP99_RS05780	1203691..1204074	+	384	WP_060564310.1	class I SAM-dependent methyltransferase	-
BSP99_RS05785	1204224..1205249	-	1026	WP_060564311.1	hypothetical protein	-
BSP99_RS05790	1205254..1205832	-	579	WP_060564312.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-74)

Antitoxin

• Antitoxin ParD (1-76)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11529.07 Da
• Isoelectric Point: 10.6281

>T68870 WP_075348157.1 NZ_CP018175:1200876-1201175 [Corynebacterium glutamicum]
VSRYLLTPAAQHDLSLIWDFTESRWGISQAKKYIREIQSAVEYVAQDANRGRSREEIRLGYKSTAVGSHVIFYVQRTSHW
KAMKQPVWRPTSARQFVTS

Nucleotide

• Length: 300 bp

>T68870 NZ_CP018175:1200876-1201175 [Corynebacterium glutamicum]
GTGAGCAGGTACCTTCTTACACCGGCTGCACAGCATGATCTCTCCTTGATTTGGGATTTCACCGAGAGTCGTTGGGGTAT
AAGCCAAGCAAAGAAGTATATCCGTGAGATTCAATCAGCAGTGGAATATGTGGCACAAGATGCGAACCGTGGCCGTAGTC
GTGAGGAAATTCGCTTAGGTTATAAAAGCACTGCGGTAGGCAGCCATGTCATATTTTATGTCCAGCGCACGAGCCATTGG
AAGGCAATGAAACAGCCTGTCTGGAGACCGACATCGGCCAGGCAGTTCGTGACCTCATAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8475.39 Da
• Isoelectric Point: 4.1948

>AT68870 WP_060564305.1 NZ_CP018175:1200646-1200879 [Corynebacterium glutamicum]
MAMNTSISLDDHFASFLSEQVESGRYQTASEVIRAGLRLLEEREARLTALRAALVNGEMSGEAEEFDFDAFIASKSS

Nucleotide

• Length: 234 bp

>AT68870 NZ_CP018175:1200646-1200879 [Corynebacterium glutamicum]
ATGGCCATGAATACTTCCATCAGTCTTGATGATCATTTCGCTTCGTTCCTCAGTGAGCAGGTTGAATCCGGTCGGTACCA
GACAGCGAGTGAGGTCATCCGTGCAGGTCTGCGCTTGTTGGAGGAGCGGGAAGCTCGTCTAACTGCTTTACGTGCGGCGC
TTGTAAATGGAGAGATGAGTGGTGAGGCAGAAGAATTTGATTTTGATGCCTTTATCGCATCGAAAAGCTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B4WJV4