Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2317793..2318405 Replicon chromosome
Accession NZ_CP018171
Organism Mesorhizobium oceanicum strain B7

Toxin (Protein)


Gene name PumA Uniprot ID A0A1L3SR51
Locus tag BSQ44_RS11460 Protein ID WP_072604154.1
Coordinates 2318109..2318405 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A1L3SR79
Locus tag BSQ44_RS11455 Protein ID WP_072604152.1
Coordinates 2317793..2318107 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSQ44_RS11435 2314555..2315487 + 933 WP_072604148.1 TerC family protein -
BSQ44_RS11440 2315808..2316608 + 801 WP_072608010.1 sel1 repeat family protein -
BSQ44_RS11445 2316621..2316911 - 291 WP_072608011.1 hypothetical protein -
BSQ44_RS11450 2316958..2317746 - 789 WP_072604150.1 exodeoxyribonuclease III -
BSQ44_RS11455 2317793..2318107 - 315 WP_072604152.1 putative addiction module antidote protein Antitoxin
BSQ44_RS11460 2318109..2318405 - 297 WP_072604154.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSQ44_RS11465 2318543..2319952 - 1410 WP_072604156.1 type I glutamate--ammonia ligase -
BSQ44_RS11470 2320000..2320338 - 339 WP_072604158.1 P-II family nitrogen regulator -
BSQ44_RS11475 2320642..2322171 + 1530 WP_072604161.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
BSQ44_RS11480 2322178..2322561 - 384 WP_072604164.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Cro/C1-type helix-turn-helix domain

(46-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11297.03 Da        Isoelectric Point: 10.5147

>T68864 WP_072604154.1 NZ_CP018171:c2318405-2318109 [Mesorhizobium oceanicum]
MFELKQTETFRKWWTRLKDERARGLIFARLDRLAYGHVGDVKPVGGGISEVRIHHGPGYRVYLQQRGSTLIVLLCGGDKS
TQAKDIRTAKRLAEEWKE

Download         Length: 297 bp

>T68864 NZ_CP018171:c2318405-2318109 [Mesorhizobium oceanicum]
ATGTTCGAGCTGAAGCAGACGGAGACGTTCAGGAAGTGGTGGACGCGCCTCAAGGATGAGCGTGCCCGCGGTCTGATCTT
CGCACGGCTCGACCGACTGGCCTACGGACACGTAGGCGACGTCAAGCCGGTGGGTGGCGGCATAAGCGAGGTGCGCATCC
ACCACGGTCCCGGCTACCGCGTTTATCTCCAGCAGCGCGGCAGCACCCTCATTGTCCTCCTGTGTGGCGGCGACAAGAGC
ACACAGGCGAAGGACATCAGAACCGCCAAACGTCTGGCTGAAGAATGGAAGGAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 10853.25 Da        Isoelectric Point: 4.7906

>AT68864 WP_072604152.1 NZ_CP018171:c2318107-2317793 [Mesorhizobium oceanicum]
VAEVLTTFDPAEGLTSDEAIASFMAEAFASEDAGYIAHALGVVARAKGMTQIANETGLSREQLYRSFSDKGNPTLKTTIA
VMKALGIELTARPAHALAGPSREG

Download         Length: 315 bp

>AT68864 NZ_CP018171:c2318107-2317793 [Mesorhizobium oceanicum]
GTGGCCGAGGTACTGACGACGTTCGACCCCGCCGAGGGACTGACCTCCGACGAGGCAATAGCGTCCTTCATGGCGGAGGC
GTTCGCTTCCGAGGATGCCGGATATATCGCGCACGCGCTTGGCGTCGTGGCGCGCGCGAAGGGCATGACCCAGATCGCGA
ACGAGACGGGGCTTTCGCGCGAGCAGCTCTACCGGTCGTTCAGCGACAAAGGGAATCCTACCCTCAAGACAACCATCGCG
GTGATGAAGGCGCTCGGCATCGAACTGACGGCCAGACCCGCGCATGCCCTGGCTGGCCCGAGCCGGGAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L3SR51

Antitoxin

Source ID Structure
AlphaFold DB A0A1L3SR79

References