Detailed information of TA system TA068834

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 909530..910028
• Replicon: chromosome
• Accession: NZ_CP018137
• Organism: Streptococcus pneumoniae strain SP61

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BOC71_RS04965
• Protein ID: WP_001823353.1
• Coordinates: 909774..910028 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: BOC71_RS04960
• Protein ID: WP_000208080.1
• Coordinates: 909530..909772 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOC71_RS04940	905352..906527	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
BOC71_RS04945	906582..907286	+	705	WP_000722076.1	response regulator transcription factor	-
BOC71_RS04950	907279..908628	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
BOC71_RS04955	908630..909439	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
BOC71_RS04960	909530..909772	+	243	WP_000208080.1	hypothetical protein	Antitoxin
BOC71_RS04965	909774..910028	+	255	WP_001823353.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BOC71_RS04970	910075..910848	+	774	WP_000731129.1	ion transporter	-
BOC71_RS04975	911164..912510	-	1347	WP_001814919.1	IS1380-like element ISSpn5 family transposase	-
BOC71_RS04985	912819..913805	-	987	WP_000204727.1	L-lactate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	911164..912510	1346

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10094.81 Da
• Isoelectric Point: 10.7632

>T68834 WP_001823353.1 NZ_CP018137:909774-910028 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATPEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T68834 NZ_CP018137:909774-910028 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAATCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCCAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT68834 WP_000208080.1 NZ_CP018137:909530-909772 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT68834 NZ_CP018137:909530-909772 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7