Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1155922..1156420 Replicon chromosome
Accession NZ_CP018136
Organism Streptococcus pneumoniae strain SP49

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag BMJ42_RS06450 Protein ID WP_001809704.1
Coordinates 1155922..1156176 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag BMJ42_RS06455 Protein ID WP_000208080.1
Coordinates 1156178..1156420 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BMJ42_RS06435 1151195..1153663 - 2469 WP_001152989.1 DNA gyrase subunit A -
BMJ42_RS06440 1153857..1154843 + 987 WP_000204727.1 L-lactate dehydrogenase -
BMJ42_RS06445 1155099..1155875 - 777 WP_000731138.1 ion transporter -
BMJ42_RS06450 1155922..1156176 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BMJ42_RS06455 1156178..1156420 - 243 WP_000208080.1 hypothetical protein Antitoxin
BMJ42_RS06460 1156511..1157320 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
BMJ42_RS06465 1157322..1158671 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
BMJ42_RS06470 1158664..1159368 - 705 WP_000722076.1 response regulator transcription factor -
BMJ42_RS06475 1159423..1160598 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T68832 WP_001809704.1 NZ_CP018136:c1156176-1155922 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T68832 NZ_CP018136:c1156176-1155922 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGATCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT68832 WP_000208080.1 NZ_CP018136:c1156420-1156178 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT68832 NZ_CP018136:c1156420-1156178 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References