Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 16875..17394 Replicon plasmid unnamed3
Accession NZ_CP018131
Organism Enterococcus faecium strain A_020709_82

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag BSG28_RS15730 Protein ID WP_000588503.1
Coordinates 16875..17132 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag BSG28_RS15735 Protein ID WP_000388479.1
Coordinates 17125..17394 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG28_RS15700 11914..12204 - 291 WP_000026576.1 hypothetical protein -
BSG28_RS15705 12340..12519 - 180 WP_001021554.1 hypothetical protein -
BSG28_RS15710 12516..12866 - 351 WP_000568378.1 hypothetical protein -
BSG28_RS15715 12859..14184 - 1326 WP_000969590.1 Y-family DNA polymerase -
BSG28_RS15720 14634..15248 + 615 WP_001261742.1 recombinase family protein -
BSG28_RS15725 15413..16237 - 825 WP_001809248.1 hypothetical protein -
BSG28_RS16100 16261..16416 - 156 WP_002347142.1 hypothetical protein -
BSG28_RS15730 16875..17132 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
BSG28_RS15735 17125..17394 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BSG28_RS15740 17525..17704 - 180 WP_001120991.1 hypothetical protein -
BSG28_RS15750 18085..18780 - 696 WP_002326819.1 hypothetical protein -
BSG28_RS15755 18842..19516 + 675 WP_060475447.1 IS6 family transposase -
BSG28_RS15760 19542..20837 - 1296 WP_002297218.1 ISL3-like element ISEfa11 family transposase -
BSG28_RS15885 20970..21044 + 75 Protein_30 IS6 family transposase -
BSG28_RS15770 21450..21653 + 204 WP_002311910.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-III / ant(6)-Ia / erm(B) - 1..23736 23736


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T68829 WP_000588503.1 NZ_CP018131:c17132-16875 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T68829 NZ_CP018131:c17132-16875 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT68829 WP_000388479.1 NZ_CP018131:c17394-17125 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT68829 NZ_CP018131:c17394-17125 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References