Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 16875..17394 | Replicon | plasmid unnamed3 |
Accession | NZ_CP018131 | ||
Organism | Enterococcus faecium strain A_020709_82 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | BSG28_RS15730 | Protein ID | WP_000588503.1 |
Coordinates | 16875..17132 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | BSG28_RS15735 | Protein ID | WP_000388479.1 |
Coordinates | 17125..17394 (-) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BSG28_RS15700 | 11914..12204 | - | 291 | WP_000026576.1 | hypothetical protein | - |
BSG28_RS15705 | 12340..12519 | - | 180 | WP_001021554.1 | hypothetical protein | - |
BSG28_RS15710 | 12516..12866 | - | 351 | WP_000568378.1 | hypothetical protein | - |
BSG28_RS15715 | 12859..14184 | - | 1326 | WP_000969590.1 | Y-family DNA polymerase | - |
BSG28_RS15720 | 14634..15248 | + | 615 | WP_001261742.1 | recombinase family protein | - |
BSG28_RS15725 | 15413..16237 | - | 825 | WP_001809248.1 | hypothetical protein | - |
BSG28_RS16100 | 16261..16416 | - | 156 | WP_002347142.1 | hypothetical protein | - |
BSG28_RS15730 | 16875..17132 | - | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
BSG28_RS15735 | 17125..17394 | - | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
BSG28_RS15740 | 17525..17704 | - | 180 | WP_001120991.1 | hypothetical protein | - |
BSG28_RS15750 | 18085..18780 | - | 696 | WP_002326819.1 | hypothetical protein | - |
BSG28_RS15755 | 18842..19516 | + | 675 | WP_060475447.1 | IS6 family transposase | - |
BSG28_RS15760 | 19542..20837 | - | 1296 | WP_002297218.1 | ISL3-like element ISEfa11 family transposase | - |
BSG28_RS15885 | 20970..21044 | + | 75 | Protein_30 | IS6 family transposase | - |
BSG28_RS15770 | 21450..21653 | + | 204 | WP_002311910.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aph(3')-III / ant(6)-Ia / erm(B) | - | 1..23736 | 23736 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T68829 WP_000588503.1 NZ_CP018131:c17132-16875 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T68829 NZ_CP018131:c17132-16875 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT68829 WP_000388479.1 NZ_CP018131:c17394-17125 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT68829 NZ_CP018131:c17394-17125 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |