Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parDE/RelE-RHH |
Location | 1799..2346 | Replicon | plasmid pMRSN346355_61.1 |
Accession | NZ_CP018125 | ||
Organism | Escherichia coli strain MRSN346355 |
Toxin (Protein)
Gene name | parE | Uniprot ID | E9LLH3 |
Locus tag | BSG24_RS26665 | Protein ID | WP_000969996.1 |
Coordinates | 2065..2346 (+) | Length | 94 a.a. |
Antitoxin (Protein)
Gene name | parD | Uniprot ID | A0A3Z6J955 |
Locus tag | BSG24_RS26660 | Protein ID | WP_071940833.1 |
Coordinates | 1799..2068 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BSG24_RS26645 | 26..883 | + | 858 | WP_034169384.1 | incFII family plasmid replication initiator RepA | - |
BSG24_RS26660 | 1799..2068 | + | 270 | WP_071940833.1 | hypothetical protein | Antitoxin |
BSG24_RS26665 | 2065..2346 | + | 282 | WP_000969996.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
BSG24_RS26670 | 2419..3468 | + | 1050 | WP_000058249.1 | hypothetical protein | - |
BSG24_RS26675 | 3769..3897 | + | 129 | Protein_5 | DNA-binding protein | - |
BSG24_RS26680 | 4162..4506 | - | 345 | WP_001444423.1 | plasmid partitioning/stability family protein | - |
BSG24_RS26685 | 4509..5471 | - | 963 | WP_000959875.1 | plasmid segregation protein ParM | - |
BSG24_RS26690 | 6021..6923 | + | 903 | WP_077253143.1 | DUF1281 domain-containing protein | - |
BSG24_RS27860 | 6920..7231 | + | 312 | WP_001732000.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | - | - | 1..61085 | 61085 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10893.57 Da Isoelectric Point: 8.4615
>T68826 WP_000969996.1 NZ_CP018125:2065-2346 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP
Download Length: 282 bp
>T68826 NZ_CP018125:2065-2346 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAACCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACCGCACAGAAGTGGCCATAG
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAACCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACCGCACAGAAGTGGCCATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 10311.69 Da Isoelectric Point: 10.1734
>AT68826 WP_071940833.1 NZ_CP018125:1799-2068 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLKRGDVLPHDMVESSATAWRD
EMSRKVTGK
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLKRGDVLPHDMVESSATAWRD
EMSRKVTGK
Download Length: 270 bp
>AT68826 NZ_CP018125:1799-2068 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCAAGCGCGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCACCGGTAAATGA
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCAAGCGCGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCACCGGTAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | E9LLH3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3Z6J955 |