68778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3228470..3229124 Replicon chromosome
Accession NZ_CP018115
Organism Escherichia coli strain MRSN346638

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag BSG23_RS16610 Protein ID WP_000244781.1
Coordinates 3228470..3228877 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag BSG23_RS16615 Protein ID WP_000354046.1
Coordinates 3228858..3229124 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG23_RS16590 3224427..3226160 - 1734 WP_021523238.1 single-stranded-DNA-specific exonuclease RecJ -
BSG23_RS16595 3226166..3226876 - 711 WP_001521231.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BSG23_RS16600 3226901..3227797 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
BSG23_RS16605 3227909..3228430 + 522 WP_001521233.1 flavodoxin FldB -
BSG23_RS16610 3228470..3228877 - 408 WP_000244781.1 protein YgfX Toxin
BSG23_RS16615 3228858..3229124 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
BSG23_RS16620 3229367..3230347 + 981 WP_000886050.1 tRNA-modifying protein YgfZ -
BSG23_RS16625 3230424..3231083 - 660 WP_000250269.1 hemolysin III family protein -
BSG23_RS16630 3231247..3231558 - 312 WP_001182949.1 N(4)-acetylcytidine aminohydrolase -
BSG23_RS16635 3231603..3233036 + 1434 WP_001521235.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T68778 WP_000244781.1 NZ_CP018115:c3228877-3228470 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T68778 NZ_CP018115:c3228877-3228470 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATCTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT68778 WP_000354046.1 NZ_CP018115:c3229124-3228858 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT68778 NZ_CP018115:c3229124-3228858 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAGTGTGACGATCCCGATC
TGTTTAACTGGCTGATGAACCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References