Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 1799..2346 Replicon plasmid pMRSN346595_62.2
Accession NZ_CP018113
Organism Escherichia coli strain MRSN346595

Toxin (Protein)


Gene name parE Uniprot ID E9LLH3
Locus tag BSG21_RS26665 Protein ID WP_000969996.1
Coordinates 2065..2346 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A3Z6J955
Locus tag BSG21_RS26660 Protein ID WP_071940833.1
Coordinates 1799..2068 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG21_RS26645 26..883 + 858 WP_034169384.1 incFII family plasmid replication initiator RepA -
BSG21_RS26660 1799..2068 + 270 WP_071940833.1 hypothetical protein Antitoxin
BSG21_RS26665 2065..2346 + 282 WP_000969996.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BSG21_RS26670 2419..3468 + 1050 WP_000058249.1 hypothetical protein -
BSG21_RS26675 3769..3897 + 129 Protein_5 DNA-binding protein -
BSG21_RS26680 4162..4506 - 345 WP_001444423.1 plasmid partitioning/stability family protein -
BSG21_RS26685 4509..5471 - 963 WP_000959875.1 plasmid segregation protein ParM -
BSG21_RS26690 6021..6923 + 903 WP_077253143.1 DUF1281 domain-containing protein -
BSG21_RS27910 6920..7231 + 312 WP_001732000.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..62157 62157


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10893.57 Da        Isoelectric Point: 8.4615

>T68760 WP_000969996.1 NZ_CP018113:2065-2346 [Escherichia coli]
MMEIFWTMLASQDRKRIREYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T68760 NZ_CP018113:2065-2346 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGAAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAACCGTATAAAGGTCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGTGTATTGCATACCGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10311.69 Da        Isoelectric Point: 10.1734

>AT68760 WP_071940833.1 NZ_CP018113:1799-2068 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLKRGDVLPHDMVESSATAWRD
EMSRKVTGK

Download         Length: 270 bp

>AT68760 NZ_CP018113:1799-2068 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATTGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCAAGCGCGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGTCACCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E9LLH3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z6J955

References