68697

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 350344..351038 Replicon chromosome
Accession NZ_CP018103
Organism Escherichia coli strain MRSN352231

Toxin (Protein)


Gene name ypjF Uniprot ID A0A1X9TDN4
Locus tag BSG22_RS01820 Protein ID WP_001094398.1
Coordinates 350670..351038 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag BSG22_RS01815 Protein ID WP_077249034.1
Coordinates 350344..350649 (+) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BSG22_RS01775 346294..346749 + 456 WP_000581506.1 hypothetical protein -
BSG22_RS29040 346850..347058 + 209 Protein_314 DUF905 family protein -
BSG22_RS01785 347159..347980 + 822 WP_001234565.1 DUF945 domain-containing protein -
BSG22_RS01795 348322..348795 + 474 WP_000855059.1 antirestriction protein -
BSG22_RS01800 348811..349287 + 477 WP_001424026.1 RadC family protein -
BSG22_RS01805 349356..349577 + 222 WP_000692345.1 DUF987 domain-containing protein -
BSG22_RS01810 349596..350240 + 645 WP_000086755.1 hypothetical protein -
BSG22_RS01815 350344..350649 + 306 WP_077249034.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
BSG22_RS01820 350670..351038 + 369 WP_001094398.1 TA system toxin CbtA family protein Toxin
BSG22_RS01825 351359..351697 - 339 Protein_322 LysR family transcriptional regulator -
BSG22_RS01830 351748..352704 - 957 WP_000121359.1 molybdenum cofactor insertion chaperone PaoD -
BSG22_RS01835 352714..354912 - 2199 WP_000667026.1 aldehyde oxidoreductase molybdenum-binding subunit PaoC -
BSG22_RS01840 354909..355865 - 957 WP_000643333.1 aldehyde oxidoreductase FAD-binding subunit PaoB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-111)

Antitoxin

(3-100)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13581.73 Da        Isoelectric Point: 7.7465

>T68697 WP_001094398.1 NZ_CP018103:350670-351038 [Escherichia coli]
MNTLPATISPAAKPCPSPVAVWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
NSQVQAPYLTATDILQARKACGLMSRCSYRDVSNIVLSRSRL

Download         Length: 369 bp

>T68697 NZ_CP018103:350670-351038 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCTCCGGCGGCGAAGCCCTGTCCGTCGCCCGTTGCAGTCTGGCAAATGTTACTTAC
TCGTTTGCTTGAGCAGCACTATGGCCTAATGCTAAGCGACACACCTTTTAGCGATGAAACCGTTATAAAGGAGCATATTG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTGGTAGAGAAATATGAGTTAGTTCGTATTGATCGCAATGGATTT
AACTCTCAGGTACAAGCACCATATTTGACTGCGACAGACATTCTTCAAGCCAGGAAAGCGTGCGGGTTGATGAGCCGGTG
TTCTTACAGAGATGTAAGTAATATTGTTCTTAGCCGATCACGGTTGTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11263.85 Da        Isoelectric Point: 6.0454

>AT68697 WP_077249034.1 NZ_CP018103:350344-350649 [Escherichia coli]
MVGLPYTVTPCSGTRLVQEGNRLYYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCFTLYHNGFT
CEADTLGSCGYVYIAIYPTQL

Download         Length: 306 bp

>AT68697 NZ_CP018103:350344-350649 [Escherichia coli]
CTGGTGGGGCTACCCTACACCGTGACGCCCTGTTCTGGCACCCGTCTGGTGCAGGAGGGCAACCGACTGTACTATTTGGC
TGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAAAGCCTGAAGCTGGATGTCGTATTTCCACATTTTATCAGTC
AGATGGAATCGATGCTGACCACTGGTGAAATGAATCCCCGCCATGCCCACTGTTTCACCCTGTACCACAACGGTTTCACC
TGCGAAGCCGATACCCTTGGTAGTTGCGGCTATGTATACATCGCCATTTATCCCACTCAGCTCTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1X9TDN4


Antitoxin

Source ID Structure

References