Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1074448..1076131 Replicon chromosome
Accession NZ_CP018101
Organism Delftia sp. HK171

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag BO996_RS04885 Protein ID WP_071954160.1
Coordinates 1074448..1075302 (+) Length 285 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID F6ALN8
Locus tag BO996_RS04890 Protein ID WP_012202883.1
Coordinates 1075325..1076131 (+) Length 269 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BO996_RS04860 1070317..1070808 + 492 WP_016449824.1 Lrp/AsnC family transcriptional regulator -
BO996_RS04865 1070890..1071480 + 591 WP_013804518.1 TetR/AcrR family transcriptional regulator -
BO996_RS04870 1071617..1072501 + 885 WP_071954159.1 NAD(P)-dependent oxidoreductase -
BO996_RS04875 1072524..1073720 + 1197 WP_071957026.1 MFS transporter -
BO996_RS04880 1073903..1074433 + 531 WP_012202881.1 cupin domain-containing protein -
BO996_RS04885 1074448..1075302 + 855 WP_071954160.1 alpha/beta fold hydrolase Toxin
BO996_RS04890 1075325..1076131 + 807 WP_012202883.1 IclR family transcriptional regulator Antitoxin
BO996_RS04895 1076186..1076983 + 798 WP_071954161.1 aspartate dehydrogenase -
BO996_RS04900 1077095..1077856 + 762 WP_071954162.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
BO996_RS04905 1077869..1078177 - 309 WP_013804512.1 XRE family transcriptional regulator -
BO996_RS04910 1078174..1078521 - 348 WP_071954163.1 type II toxin-antitoxin system RelE/ParE family toxin -
BO996_RS04915 1078839..1079120 - 282 WP_071954164.1 hypothetical protein -
BO996_RS04920 1079953..1080723 + 771 WP_071954165.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(43-270)

Antitoxin

Transcription regulator IclR, C-terminal

(137-255)


Sequences

Toxin        


Download         Length: 285 a.a.        Molecular weight: 29603.95 Da        Isoelectric Point: 7.4022

>T68690 WP_071954160.1 NZ_CP018101:1074448-1075302 [Delftia sp. HK171]
MTAQTLQRMEQRLQAQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWMDVALALAPRTRVLAWDAPGYGR
STPLAPAVPTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQ
GRLAALQEKGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVV
TPPAACAAWAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 855 bp

>T68690 NZ_CP018101:1074448-1075302 [Delftia sp. HK171]
ATGACCGCGCAGACGCTGCAGCGCATGGAACAGCGCCTTCAGGCGCAGTTCCCCGAACACCTCATCGCCCTGCCCGGTGG
CGCTCAGGCCGCCTGGCGCGAGGCCGGCGACACGGCCTCGGACTTTGCCGTGGTGATGCTGCACGGCATCAGCTCGGGCG
CCGCCTCCTGGATGGACGTGGCCCTGGCGCTGGCGCCGCGCACGCGCGTGCTGGCCTGGGACGCGCCCGGCTATGGCCGC
TCCACGCCGCTGGCACCCGCCGTGCCCACGGGCGCCGACTACGCCCGCGTGCTGGAGCAGTCGCTGCAGGCGCTGGGCGT
GCGCCGCTGCCTGCTGGTGGGCCACTCGCTGGGTGCGCTCATGGGCACGCCCTGGGCGGTGCAGGCCGGTGCCGGGCGCG
TGCAGCAACTGGTGCTGATCAGCCCCGCTGGCGGCTATGGCGCACCCGGCATGGGCGAGCAGCAGGCCAAGGTACGCCAG
GGCCGTCTTGCGGCCCTGCAGGAAAAAGGCATCGAAGGCCTGGCCGCCGCCATCGACCAGCGCCTGGTCTCGCCCGCCGC
GCCCGAGCCCGTGCGCCAATGGGTGCGCTGGAACACGGCGCGCCTGCATGCTGCCGGCTACGCCCAGGCCGTGGAGCTGC
TGTGCGGCAGTGACCTGGGGCAGGCGGCGGGGCAACTGGCCATGCCGGTCGAGGTCTGGGTGGGCGAGCACGACGTGGTC
ACGCCGCCCGCTGCCTGCGCGGCCTGGGCCGCAAGGCTGGGCGCGCGGTACGTTACGCTTGCGGCAGCCGGCCATGCCTC
TGTCGTCGAACAACCTGCGGATGTCGCACAGAGGCTGGCCACCCTGCTGACCTGA

Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29330.45 Da        Isoelectric Point: 5.7085

>AT68690 WP_012202883.1 NZ_CP018101:1075325-1076131 [Delftia sp. HK171]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Download         Length: 807 bp

>AT68690 NZ_CP018101:1075325-1076131 [Delftia sp. HK171]
ATGAGCGACACCTCCGAAACCCTCTCGAACGACAACGACCGCTACACCGTCCCCGCGCTGGAGCGCGGCCTGCGCCTGCT
GGCCTGCTTCACGCCTTCGCAGCCCGTGTGGAGCGCGCCCGACCTGGCGCGCACCCTGGCGCTGCCGCGTTCCACGGTGT
TCCGGATGCTGACGACGCTGGAGAACATGGGGTATCTGCAACGCTCGGGCACCGAGTACCGGCTGGGCCTGTCCGTGCTG
CGCCTGGGCTACGACTACCTGTCCACCCAGCCGCTGGCCCAGCTGGCCGAGCCCGTGCTGCAGGCGCTGTGCGAGCGCCT
GGGCTTCACCACCAACCTGGCGCTGCTGGACGGCACCTCCGTGGTCTACGTGGCGCGCATTGCGCCGGCCGGCGCCTTCC
AGGGCGCCGTGCGCGTGGGCTCGCGCCTGCCGGCCCATGCCACCGTGCTGGGCCGCGCCCTGCTGCAGGACATGGACGCA
GACCAGCTGCGCGAACTCTTCGGCGGCAGCGAGTTGCCGCAATTCTCGGAAAGCACCCCGCGCGACGTGCAGCAACTGCA
GCAGCTGCTGCTGCAGGACCGCGAGCGCGGCTACGCCATGGGCGAGGGCTTCTACGAGCCCGGCGTCTCCAGCATTGCCG
CACCCGTGCGCGATGCGCAGGGCCGCATCATCGCGGGCCTGGGCATGGCCGTGGCCTTTACCGAAATCGCACCCGGGCGC
ATGGCGCACTGGGTGGAACAGGTGCGCGAGGCCGCCGTCGAACTGACGGGCCACCTGCGCACCCAGCATCCTGGTTTTCT
GCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A031HDN8

References