Detailed information of TA system TA068687

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YefM(antitoxin)
• Location: 4875470..4876041
• Replicon: chromosome
• Accession: NZ_CP018099
• Organism: Caldithrix abyssi DSM 13497 strain LF13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H1XVU0
• Locus tag: Cabys_RS19170
• Protein ID: WP_006927691.1
• Coordinates: 4875748..4876041 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H1XVU1
• Locus tag: Cabys_RS19165
• Protein ID: WP_006927692.1
• Coordinates: 4875470..4875748 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Cabys_RS19155	4872609..4873430	+	822	WP_006927694.1	DUF3800 domain-containing protein	-
Cabys_RS19160	4873567..4874502	+	936	WP_006927682.1	hypothetical protein	-
Cabys_RS19165	4875470..4875748	+	279	WP_006927692.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Cabys_RS19170	4875748..4876041	+	294	WP_006927691.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Cabys_RS19180	4877327..4878064	+	738	WP_006927690.1	hypothetical protein	-
Cabys_RS19185	4878198..4878974	+	777	WP_006927689.1	hypothetical protein	-
Cabys_RS19190	4878986..4879501	+	516	WP_006927688.1	hypothetical protein	-
Cabys_RS19195	4879682..4880545	+	864	WP_006927687.1	transporter substrate-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	4872456..4889135	16679

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11514.51 Da
• Isoelectric Point: 8.4663

>T68687 WP_006927691.1 NZ_CP018099:4875748-4876041 [Caldithrix abyssi DSM 13497]
MKIIWSPRSKVQLIDIAEYISLDKPEAAHRWLENVFQEVEKLKLFPKSGRKVPEINQEDIREIIFGNYRIIYKIEIDLII
IASVRHGKQLLDKDELK

Nucleotide

• Length: 294 bp

>T68687 NZ_CP018099:4875748-4876041 [Caldithrix abyssi DSM 13497]
ATGAAAATTATCTGGTCACCGCGTTCAAAGGTTCAATTGATAGACATTGCGGAATATATTTCTTTAGACAAGCCAGAAGC
AGCTCATAGATGGTTAGAAAATGTATTTCAAGAAGTTGAAAAGCTAAAATTATTTCCAAAGTCAGGCCGTAAAGTACCAG
AAATAAATCAAGAAGATATACGAGAAATTATATTTGGTAATTATAGGATAATCTACAAAATTGAAATAGATTTAATAATT
ATTGCTTCAGTTCGTCATGGTAAACAATTATTAGATAAGGATGAATTAAAATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10738.45 Da
• Isoelectric Point: 9.8968

>AT68687 WP_006927692.1 NZ_CP018099:4875470-4875748 [Caldithrix abyssi DSM 13497]
MRTINFEQDIKSLSEFRANASKLLKQINNTRRPLIITQHGKSKAVLMDVTDYQNLIEKLEILEDIYVSEKQIAEGKGIPH
NQVKEELLKRFK

Nucleotide

• Length: 279 bp

>AT68687 NZ_CP018099:4875470-4875748 [Caldithrix abyssi DSM 13497]
ATGAGAACAATAAATTTTGAACAAGATATAAAATCTTTATCTGAATTCAGAGCGAATGCTTCAAAACTATTAAAACAAAT
AAATAATACCCGTCGTCCTTTAATAATAACTCAACATGGAAAAAGTAAAGCCGTATTAATGGATGTAACTGATTATCAGA
ATCTAATTGAAAAATTAGAAATATTAGAAGATATTTATGTTTCAGAAAAACAGATAGCAGAAGGGAAAGGGATTCCGCAT
AATCAAGTTAAGGAAGAATTGCTAAAAAGATTTAAATAA

Structures

Toxin

• AlphaFold DB: H1XVU0

Antitoxin

• AlphaFold DB: H1XVU1