Detailed information of TA system TA068686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-UPF0150
• Location: 2774978..2775411
• Replicon: chromosome
• Accession: NZ_CP018099
• Organism: Caldithrix abyssi DSM 13497 strain LF13

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: Cabys_RS10805
• Protein ID: WP_006930469.1
• Coordinates: 2774978..2775202 (-)
• Length: 75 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: H1XWA6
• Locus tag: Cabys_RS10810
• Protein ID: WP_006930470.1
• Coordinates: 2775199..2775411 (-)
• Length: 71 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Cabys_RS10795	2771976..2772521	-	546	WP_006930467.1	cytochrome c family protein	-
Cabys_RS10800	2773483..2774592	-	1110	WP_006930468.1	hypothetical protein	-
Cabys_RS10805	2774978..2775202	-	225	WP_006930469.1	type II toxin-antitoxin system HicA family toxin	Toxin
Cabys_RS10810	2775199..2775411	-	213	WP_006930470.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
Cabys_RS10815	2776018..2780253	-	4236	WP_006930471.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (9-65)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-60)

Sequences

Toxin

Protein

• Length: 75 a.a.
• Molecular weight: 8421.92 Da
• Isoelectric Point: 11.1462

>T68686 WP_006930469.1 NZ_CP018099:c2775202-2774978 [Caldithrix abyssi DSM 13497]
VSTLPRISGRDVVAALSKIGYERDRQKGSHIVLRQIAYPHRRVVVPDHHEIAKGTLRKIIKQVGLTVEEFKKLL

Nucleotide

• Length: 225 bp

>T68686 NZ_CP018099:c2775202-2774978 [Caldithrix abyssi DSM 13497]
GTGAGTACACTTCCTCGAATATCAGGACGTGATGTGGTGGCAGCGTTGTCAAAGATTGGTTATGAAAGAGACAGACAGAA
AGGCAGTCATATAGTTTTGCGACAGATTGCGTATCCTCATAGACGAGTTGTTGTTCCAGATCATCACGAAATTGCGAAAG
GTACCTTACGGAAGATCATAAAACAAGTTGGATTGACTGTTGAAGAATTTAAGAAACTTCTGTAA

Antitoxin

Protein

• Length: 71 a.a.
• Molecular weight: 7704.83 Da
• Isoelectric Point: 4.0232

>AT68686 WP_006930470.1 NZ_CP018099:c2775411-2775199 [Caldithrix abyssi DSM 13497]
MKYRVIIEQDEDGVFVAEVPSLPGCISQGITRAEALKNIQEAIAVYIESLKAHNEPIPPSIDEEIVEVVV

Nucleotide

• Length: 213 bp

>AT68686 NZ_CP018099:c2775411-2775199 [Caldithrix abyssi DSM 13497]
ATGAAATATCGAGTTATTATTGAACAAGATGAAGATGGAGTGTTTGTGGCAGAGGTACCTTCTCTGCCAGGTTGTATTTC
TCAAGGAATAACACGTGCAGAGGCTTTAAAAAATATTCAAGAGGCAATAGCAGTTTATATTGAAAGCCTGAAGGCACACA
ATGAACCTATTCCACCCTCCATAGATGAAGAAATTGTAGAGGTGGTCGTGTGA

Structures

Antitoxin

• AlphaFold DB: H1XWA6