Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-UPF0150
Location 2774978..2775411 Replicon chromosome
Accession NZ_CP018099
Organism Caldithrix abyssi DSM 13497 strain LF13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Cabys_RS10805 Protein ID WP_006930469.1
Coordinates 2774978..2775202 (-) Length 75 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID H1XWA6
Locus tag Cabys_RS10810 Protein ID WP_006930470.1
Coordinates 2775199..2775411 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Cabys_RS10795 2771976..2772521 - 546 WP_006930467.1 cytochrome c family protein -
Cabys_RS10800 2773483..2774592 - 1110 WP_006930468.1 hypothetical protein -
Cabys_RS10805 2774978..2775202 - 225 WP_006930469.1 type II toxin-antitoxin system HicA family toxin Toxin
Cabys_RS10810 2775199..2775411 - 213 WP_006930470.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
Cabys_RS10815 2776018..2780253 - 4236 WP_006930471.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(9-65)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-60)


Sequences

Toxin        


Download         Length: 75 a.a.        Molecular weight: 8421.92 Da        Isoelectric Point: 11.1462

>T68686 WP_006930469.1 NZ_CP018099:c2775202-2774978 [Caldithrix abyssi DSM 13497]
VSTLPRISGRDVVAALSKIGYERDRQKGSHIVLRQIAYPHRRVVVPDHHEIAKGTLRKIIKQVGLTVEEFKKLL

Download         Length: 225 bp

>T68686 NZ_CP018099:c2775202-2774978 [Caldithrix abyssi DSM 13497]
GTGAGTACACTTCCTCGAATATCAGGACGTGATGTGGTGGCAGCGTTGTCAAAGATTGGTTATGAAAGAGACAGACAGAA
AGGCAGTCATATAGTTTTGCGACAGATTGCGTATCCTCATAGACGAGTTGTTGTTCCAGATCATCACGAAATTGCGAAAG
GTACCTTACGGAAGATCATAAAACAAGTTGGATTGACTGTTGAAGAATTTAAGAAACTTCTGTAA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 7704.83 Da        Isoelectric Point: 4.0232

>AT68686 WP_006930470.1 NZ_CP018099:c2775411-2775199 [Caldithrix abyssi DSM 13497]
MKYRVIIEQDEDGVFVAEVPSLPGCISQGITRAEALKNIQEAIAVYIESLKAHNEPIPPSIDEEIVEVVV

Download         Length: 213 bp

>AT68686 NZ_CP018099:c2775411-2775199 [Caldithrix abyssi DSM 13497]
ATGAAATATCGAGTTATTATTGAACAAGATGAAGATGGAGTGTTTGTGGCAGAGGTACCTTCTCTGCCAGGTTGTATTTC
TCAAGGAATAACACGTGCAGAGGCTTTAAAAAATATTCAAGAGGCAATAGCAGTTTATATTGAAAGCCTGAAGGCACACA
ATGAACCTATTCCACCCTCCATAGATGAAGAAATTGTAGAGGTGGTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H1XWA6

References