68681

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1341026..1341684 Replicon chromosome
Accession NZ_CP018091
Organism Synechococcus sp. SynAce01

Toxin (Protein)


Gene name vapC Uniprot ID A0A1J0P9V6
Locus tag BM449_RS07060 Protein ID WP_071800647.1
Coordinates 1341026..1341454 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1J0PB09
Locus tag BM449_RS07065 Protein ID WP_071800648.1
Coordinates 1341451..1341684 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM449_RS07035 1336600..1337058 + 459 WP_071800643.1 GNAT family N-acetyltransferase -
BM449_RS07040 1337055..1337543 + 489 WP_071800644.1 hypothetical protein -
BM449_RS07045 1337593..1338651 + 1059 WP_120352840.1 alpha/beta hydrolase -
BM449_RS07050 1338635..1340161 - 1527 WP_071802061.1 hypothetical protein -
BM449_RS14975 1340160..1340363 + 204 WP_145536879.1 hypothetical protein -
BM449_RS14665 1340497..1340825 - 329 Protein_1405 IS1595 family transposase -
BM449_RS07060 1341026..1341454 - 429 WP_071800647.1 type II toxin-antitoxin system VapC family toxin Toxin
BM449_RS07065 1341451..1341684 - 234 WP_071800648.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BM449_RS07070 1341847..1343019 + 1173 WP_071800649.1 Fic family protein -
BM449_RS07085 1343824..1344567 + 744 WP_071800650.1 ribonuclease III -
BM449_RS07090 1344558..1344743 - 186 WP_071800651.1 DUF3252 domain-containing protein -
BM449_RS07095 1344798..1345487 + 690 WP_083544449.1 ribosome maturation factor RimM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15529.84 Da        Isoelectric Point: 5.7039

>T68681 WP_071800647.1 NZ_CP018091:c1341454-1341026 [Synechococcus sp. SynAce01]
MILLDTNICIYIINARPASVLARFKQYRMGEIGLCSVVAAELAFGVAKSGSARNRQALEMFLAPLTLQPFDERAAWAYGD
LRAELERRGTPIGSLDTMIAAHALSQQATLITNNSREFAQVPGLLLENWVPLDWVNGGDGSH

Download         Length: 429 bp

>T68681 NZ_CP018091:c1341454-1341026 [Synechococcus sp. SynAce01]
ATGATCTTGCTCGATACCAACATCTGCATTTACATCATCAATGCCAGGCCAGCGTCAGTGCTGGCGCGCTTCAAGCAGTA
CCGGATGGGCGAGATTGGTCTGTGCAGTGTGGTGGCCGCCGAGTTGGCCTTTGGTGTGGCCAAGAGTGGTTCAGCGCGCA
ACCGCCAGGCCCTGGAGATGTTTCTAGCCCCTCTCACACTTCAGCCCTTTGATGAGCGCGCCGCCTGGGCCTATGGCGAC
CTGCGTGCCGAACTGGAACGCCGGGGCACGCCAATCGGCTCTCTCGACACGATGATTGCGGCCCATGCCCTGAGCCAGCA
GGCCACGCTGATCACCAACAACAGCCGCGAGTTTGCCCAGGTTCCCGGCCTGCTCCTTGAAAACTGGGTTCCTCTCGATT
GGGTCAATGGTGGGGACGGTAGCCATTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8737.95 Da        Isoelectric Point: 4.7661

>AT68681 WP_071800648.1 NZ_CP018091:c1341684-1341451 [Synechococcus sp. SynAce01]
MDTAKLFQSGRSQAVRLPKEYRFSGSEVVVKHFGSGVLLLPIDDPWQTMEAALEAFEPGFELKREQPEIQIREAFSP

Download         Length: 234 bp

>AT68681 NZ_CP018091:c1341684-1341451 [Synechococcus sp. SynAce01]
ATGGACACTGCCAAGCTCTTTCAATCGGGCCGCAGCCAGGCGGTGCGTCTACCGAAGGAGTACCGCTTCAGCGGTAGCGA
GGTGGTGGTGAAGCACTTCGGTAGTGGCGTGCTGCTGCTGCCCATCGACGACCCCTGGCAAACCATGGAGGCCGCGTTGG
AGGCCTTCGAGCCTGGCTTTGAGCTCAAGCGCGAGCAACCCGAGATACAGATCCGGGAAGCCTTCAGCCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0P9V6

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0PB09

References