Detailed information of TA system TA068679

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 1192090..1192673
• Replicon: chromosome
• Accession: NZ_CP018091
• Organism: Synechococcus sp. SynAce01

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: BM449_RS06325
• Protein ID: WP_071800529.1
• Coordinates: 1192090..1192344 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: BM449_RS06330
• Protein ID: WP_071800530.1
• Coordinates: 1192341..1192673 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BM449_RS14450	1188999..1190495	+	1497	Protein_1255	IS5 family transposase	-
BM449_RS06320	1190643..1191700	-	1058	Protein_1256	IS5 family transposase	-
BM449_RS06325	1192090..1192344	+	255	WP_071800529.1	type II toxin-antitoxin system HicA family toxin	Toxin
BM449_RS06330	1192341..1192673	+	333	WP_071800530.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BM449_RS06335	1192840..1193142	+	303	WP_071800531.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BM449_RS06340	1193142..1193450	+	309	WP_186437626.1	putative addiction module antidote protein	-
BM449_RS06350	1193879..1194142	+	264	WP_071800533.1	type II toxin-antitoxin system RelE/ParE family toxin	-
BM449_RS14455	1194458..1194868	-	411	WP_162922850.1	transposase	-
BM449_RS14460	1194872..1195516	-	645	WP_083544436.1	transposase zinc-binding domain-containing protein	-
BM449_RS06360	1195500..1196420	-	921	Protein_1264	site-specific integrase	-
BM449_RS06365	1196764..1196976	+	213	WP_071800534.1	DUF4160 domain-containing protein	-
BM449_RS14960	1197232..1197375	-	144	WP_162922851.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1155381..1197139	41758
	-	flank	IS/Tn	-	-	1197381..1198334	953

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-75)

Antitoxin

• Uncharacterised protein family HicB (54-104)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9475.81 Da
• Isoelectric Point: 10.2915

>T68679 WP_071800529.1 NZ_CP018091:1192090-1192344 [Synechococcus sp. SynAce01]
MKRKHQRTLELIFSRPISGSLPWRDIEALFQELGGDVSERAGSRVAVVLFGEVRVFHRPHPSPDTDKGAVASIRKWLEEH
GVTS

Nucleotide

• Length: 255 bp

>T68679 NZ_CP018091:1192090-1192344 [Synechococcus sp. SynAce01]
ATGAAGCGGAAGCACCAGCGAACCCTTGAGCTGATCTTCTCCCGTCCTATAAGCGGCAGTTTGCCGTGGAGGGACATCGA
AGCCTTGTTTCAGGAGCTTGGTGGAGATGTCAGCGAGAGGGCGGGCAGCCGAGTCGCGGTCGTTCTGTTTGGCGAAGTCA
GGGTCTTCCACAGACCCCACCCATCGCCAGATACAGACAAGGGTGCTGTTGCTTCAATCCGCAAGTGGCTTGAAGAACAC
GGAGTTACATCATGA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12430.09 Da
• Isoelectric Point: 4.9626

>AT68679 WP_071800530.1 NZ_CP018091:1192341-1192673 [Synechococcus sp. SynAce01]
MNLMTVDGYHAKIEFDEETDQFRGEILGLSGGADFYGSSPDELRREFKKSLDVFLEVCEEQGIKPRKHFSGKFNLRIPPE
LHERLAMTAEVQGKSLNTLAQEAIQKSVIA

Nucleotide

• Length: 333 bp

>AT68679 NZ_CP018091:1192341-1192673 [Synechococcus sp. SynAce01]
ATGAATCTAATGACTGTGGATGGCTACCATGCCAAAATTGAATTCGACGAGGAAACGGATCAGTTTCGCGGGGAAATCCT
TGGGCTTTCTGGAGGAGCGGACTTCTATGGATCAAGCCCGGATGAACTTCGTAGAGAGTTTAAAAAGTCACTGGACGTCT
TTCTTGAGGTCTGCGAGGAGCAAGGAATTAAGCCGCGGAAACACTTTTCAGGCAAATTCAATCTTCGGATTCCGCCTGAA
CTCCATGAGAGGTTAGCGATGACTGCGGAAGTGCAGGGAAAGAGTCTTAACACGCTCGCACAGGAAGCGATCCAGAAAAG
TGTCATCGCATAG