Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1078700..1079472 Replicon chromosome
Accession NZ_CP018091
Organism Synechococcus sp. SynAce01

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1J0P9F7
Locus tag BM449_RS05710 Protein ID WP_071800441.1
Coordinates 1078972..1079472 (+) Length 167 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A1J0PA75
Locus tag BM449_RS05705 Protein ID WP_071800440.1
Coordinates 1078700..1078972 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM449_RS15210 1074954..1075142 - 189 WP_071800435.1 HIT domain-containing protein -
BM449_RS05675 1075277..1076149 + 873 WP_205526854.1 DUF3883 domain-containing protein -
BM449_RS05680 1076180..1076516 - 337 Protein_1134 HIT family protein -
BM449_RS15215 1076884..1077255 + 372 WP_071800437.1 hypothetical protein -
BM449_RS15220 1077242..1077470 + 229 Protein_1136 BrnT family toxin -
BM449_RS05695 1077430..1077636 + 207 WP_071800438.1 hypothetical protein -
BM449_RS05700 1077648..1078109 - 462 WP_205526855.1 HNH endonuclease -
BM449_RS05705 1078700..1078972 + 273 WP_071800440.1 DUF1778 domain-containing protein Antitoxin
BM449_RS05710 1078972..1079472 + 501 WP_071800441.1 GNAT family N-acetyltransferase Toxin
BM449_RS05715 1079759..1079956 - 198 WP_071800442.1 hypothetical protein -
BM449_RS05720 1080232..1080498 + 267 WP_083544624.1 nucleotidyltransferase domain-containing protein -
BM449_RS05725 1080539..1080847 + 309 WP_083544625.1 DUF86 domain-containing protein -
BM449_RS05730 1081064..1081270 + 207 WP_071802013.1 2-oxoisovalerate dehydrogenase -
BM449_RS05735 1081267..1081475 + 209 Protein_1145 type II toxin-antitoxin system HicA family toxin -
BM449_RS05740 1081730..1082023 + 294 WP_071800444.1 type II toxin-antitoxin system RelE/ParE family toxin -
BM449_RS05745 1082028..1082312 + 285 WP_198949703.1 HigA family addiction module antidote protein -
BM449_RS05750 1082385..1082585 - 201 WP_145536939.1 hypothetical protein -
BM449_RS05755 1082693..1082926 + 234 WP_071800447.1 addiction module protein -
BM449_RS15225 1083085..1083483 - 399 WP_186437637.1 hypothetical protein -
BM449_RS05765 1083551..1083754 + 204 WP_071800449.1 type II toxin-antitoxin system VapB family antitoxin -
BM449_RS05770 1083751..1084152 + 402 WP_071800450.1 PIN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1071666..1083215 11549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-83)


Sequences

Toxin        


Download         Length: 167 a.a.        Molecular weight: 17718.28 Da        Isoelectric Point: 7.8312

>T68677 WP_071800441.1 NZ_CP018091:1078972-1079472 [Synechococcus sp. SynAce01]
MDLQAPQPLAQHHSTVGFDCGDSSLDHWLQQRALTNQKGGATRSFVVCNGDDIVKAYVALASGSVAVASAPGRFRRNMPD
PIPVVVLARLAVCRSVQGRGIARALLADAFERVLQASTQIGVRGIVVHAASTEARSFYLHMGFDPSPIDPDTLLIRLSDV
AATLPF

Download         Length: 501 bp

>T68677 NZ_CP018091:1078972-1079472 [Synechococcus sp. SynAce01]
ATGGATCTGCAGGCGCCGCAGCCGCTGGCGCAGCATCACAGCACTGTCGGCTTTGACTGTGGCGATTCCAGCCTTGACCA
CTGGCTTCAGCAGCGTGCACTGACCAACCAGAAGGGCGGTGCGACGCGCAGCTTCGTGGTCTGCAATGGCGACGACATCG
TCAAGGCCTATGTAGCCCTGGCCTCCGGCTCGGTGGCCGTGGCCTCAGCCCCTGGGCGTTTCAGGCGCAACATGCCCGAT
CCCATTCCAGTGGTGGTGTTGGCGCGGTTGGCGGTCTGCCGCAGTGTCCAGGGACGAGGCATCGCTCGCGCACTGCTCGC
CGATGCGTTTGAGCGGGTGCTGCAGGCCAGCACACAGATCGGCGTGCGCGGCATCGTGGTTCATGCAGCGTCCACGGAAG
CCCGCAGCTTCTATCTCCACATGGGTTTTGATCCCTCACCCATCGACCCCGACACCCTGCTGATCCGTCTCTCGGATGTG
GCGGCCACCTTGCCGTTCTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10251.67 Da        Isoelectric Point: 11.5657

>AT68677 WP_071800440.1 NZ_CP018091:1078700-1078972 [Synechococcus sp. SynAce01]
VAATPRLSWNLRVTPDDQALIDRAVRTSGLTRTDFVLQAARNAARELLVQQAWQAISPEQFDLFLRQLDAPPTPSDRLQR
TMTAPKPWQR

Download         Length: 273 bp

>AT68677 NZ_CP018091:1078700-1078972 [Synechococcus sp. SynAce01]
GTGGCTGCCACTCCTCGACTCAGCTGGAACTTGCGGGTCACGCCCGACGATCAGGCGCTGATCGATCGCGCGGTCCGTAC
TTCTGGCCTCACCCGAACCGACTTCGTTCTGCAGGCGGCCCGCAATGCCGCCCGTGAGCTGCTGGTGCAGCAGGCCTGGC
AGGCCATTTCGCCTGAACAGTTCGACTTGTTTCTTCGCCAGCTCGACGCTCCGCCCACCCCATCGGATCGTCTACAACGC
ACCATGACGGCACCGAAGCCCTGGCAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0P9F7

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0PA75

References