68670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 6676839..6677380 Replicon chromosome
Accession NZ_CP018082
Organism Nocardia mangyaensis strain Y48

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J0VZK8
Locus tag BOX37_RS30240 Protein ID WP_071930583.1
Coordinates 6677081..6677380 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J0VZ84
Locus tag BOX37_RS30235 Protein ID WP_071930582.1
Coordinates 6676839..6677084 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOX37_RS30220 6672041..6672820 - 780 WP_156910629.1 YbaB/EbfC family nucleoid-associated protein -
BOX37_RS30225 6673443..6675914 - 2472 WP_156910630.1 hypothetical protein -
BOX37_RS30230 6675911..6676219 - 309 WP_071930581.1 hypothetical protein -
BOX37_RS30235 6676839..6677084 + 246 WP_071930582.1 hypothetical protein Antitoxin
BOX37_RS30240 6677081..6677380 + 300 WP_071930583.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BOX37_RS30245 6677503..6677849 - 347 Protein_5995 DoxX family protein -
BOX37_RS30250 6678066..6678803 - 738 WP_071930584.1 phosphoglyceromutase -
BOX37_RS34775 6678831..6679007 - 177 WP_167660011.1 hypothetical protein -
BOX37_RS30255 6679123..6680016 - 894 WP_071930585.1 ROK family protein -
BOX37_RS30260 6680206..6681381 + 1176 WP_084760392.1 lipase -
BOX37_RS30265 6681426..6681920 - 495 WP_071930586.1 YbjN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-97)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 10754.59 Da        Isoelectric Point: 8.5336

>T68670 WP_071930583.1 NZ_CP018082:6677081-6677380 [Nocardia mangyaensis]
VRPIHLARLDKTRPVLVLTREAVRPYLTRVTVAPITSTIRGLSTEVPVGRRNGLDHDCVVSCDNIVTIPVADLGKVIGYL
NADAEPALTIAIRSAFELI

Download         Length: 300 bp

>T68670 NZ_CP018082:6677081-6677380 [Nocardia mangyaensis]
GTGAGGCCCATCCACCTCGCCCGACTCGACAAAACCCGACCCGTCCTCGTACTCACCCGCGAAGCCGTCCGCCCTTACCT
CACCAGGGTCACCGTCGCACCGATCACCAGCACCATCCGCGGCTTGTCCACCGAAGTGCCTGTGGGCCGCCGCAATGGAC
TCGACCACGACTGCGTCGTCTCCTGCGACAACATCGTCACCATCCCCGTTGCCGATCTCGGCAAGGTCATCGGCTACCTC
AACGCCGACGCCGAGCCCGCCCTCACCATCGCCATCAGATCAGCGTTCGAGCTGATCTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8583.54 Da        Isoelectric Point: 4.2537

>AT68670 WP_071930582.1 NZ_CP018082:6676839-6677084 [Nocardia mangyaensis]
MSSQISIRLAEATVRYLDSTVSSGAAPSRAAIIEQALERDRLRRTAEADAAILAALAESTPDDDMNDLAAHAARTPMDDL
A

Download         Length: 246 bp

>AT68670 NZ_CP018082:6676839-6677084 [Nocardia mangyaensis]
ATGAGCTCGCAGATTTCGATTCGTCTCGCCGAGGCAACCGTCAGATACCTGGACAGCACCGTATCCAGCGGTGCTGCACC
GAGCCGCGCAGCGATCATCGAGCAAGCACTCGAACGCGACCGGCTTCGCCGAACCGCCGAGGCTGACGCCGCGATCCTTG
CCGCCCTTGCCGAAAGCACCCCAGACGACGACATGAACGACCTCGCCGCACACGCGGCACGCACGCCCATGGACGACCTC
GCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0VZK8

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0VZ84

References