68669

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 386439..386958 Replicon chromosome
Accession NZ_CP018082
Organism Nocardia mangyaensis strain Y48

Toxin (Protein)


Gene name relE Uniprot ID A0A1J0VLK5
Locus tag BOX37_RS01730 Protein ID WP_071925911.1
Coordinates 386439..386708 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1J0VLK9
Locus tag BOX37_RS01735 Protein ID WP_071925912.1
Coordinates 386701..386958 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOX37_RS01715 383824..384258 - 435 WP_071931103.1 MarR family transcriptional regulator -
BOX37_RS01720 384464..385888 + 1425 WP_084759374.1 aminotransferase class V-fold PLP-dependent enzyme -
BOX37_RS01725 385926..386414 + 489 WP_071925910.1 excalibur calcium-binding domain-containing protein -
BOX37_RS01730 386439..386708 - 270 WP_071925911.1 Txe/YoeB family addiction module toxin Toxin
BOX37_RS01735 386701..386958 - 258 WP_071925912.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BOX37_RS01740 387037..387423 - 387 WP_071925913.1 Uma2 family endonuclease -
BOX37_RS01745 387464..387982 - 519 WP_084760560.1 flavin reductase family protein -
BOX37_RS01750 388343..389116 + 774 WP_206045753.1 Fic family protein -
BOX37_RS01755 389308..389784 - 477 WP_071925915.1 EbsC protein -
BOX37_RS01760 389925..390746 + 822 WP_071925916.1 crotonase/enoyl-CoA hydratase family protein -
BOX37_RS01765 390834..391328 + 495 WP_071925917.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-66)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10135.56 Da        Isoelectric Point: 7.3147

>T68669 WP_071925911.1 NZ_CP018082:c386708-386439 [Nocardia mangyaensis]
MPERKLAFSAYGWETYTSWLARDRTVLEAANKLIAAVMTDPFAGIGKPEPLKHQLAGNWSRRITREHRLIYYVTDSEVVV
IAVGGHYDE

Download         Length: 270 bp

>T68669 NZ_CP018082:c386708-386439 [Nocardia mangyaensis]
ATGCCTGAGCGCAAGCTTGCGTTCAGCGCGTACGGGTGGGAGACGTACACATCCTGGCTCGCCAGGGATCGAACTGTCCT
CGAGGCAGCCAACAAATTGATCGCCGCCGTCATGACCGACCCTTTCGCCGGTATCGGAAAGCCCGAGCCCTTGAAGCACC
AACTGGCAGGGAATTGGTCGCGCCGCATCACCAGAGAACATCGATTGATCTACTACGTCACAGATTCCGAGGTCGTCGTC
ATCGCCGTCGGTGGACACTACGACGAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9333.37 Da        Isoelectric Point: 4.4055

>AT68669 WP_071925912.1 NZ_CP018082:c386958-386701 [Nocardia mangyaensis]
MTALPISTARQNLFKLVQQVNDDHDTVTVVTKSGENAVLVAESDWNSIQETLYVLATHGGVRLLESARDARDGKFEAHEL
IDPDA

Download         Length: 258 bp

>AT68669 NZ_CP018082:c386958-386701 [Nocardia mangyaensis]
ATGACTGCACTACCGATTTCCACCGCCCGCCAGAACCTCTTCAAGCTGGTTCAGCAGGTCAACGACGACCACGACACCGT
GACCGTCGTCACCAAGTCGGGCGAGAACGCCGTGCTCGTTGCCGAGTCGGATTGGAACTCCATCCAGGAGACCCTCTACG
TCCTCGCAACCCATGGCGGAGTCCGACTCCTTGAGTCTGCCCGCGATGCCCGCGATGGCAAGTTCGAGGCTCACGAGCTG
ATCGATCCCGATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0VLK5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0VLK9

References