Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 113043..113655 Replicon plasmid unnamed4
Accession NZ_CP018080
Organism Sulfitobacter sp. AM1-D1

Toxin (Protein)


Gene name vapC Uniprot ID A0A1J0WNY2
Locus tag BOO69_RS20695 Protein ID WP_071974258.1
Coordinates 113260..113655 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1J0WNT7
Locus tag BOO69_RS20690 Protein ID WP_071974344.1
Coordinates 113043..113270 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOO69_RS20670 108106..109125 - 1020 WP_071974343.1 1-aminocyclopropane-1-carboxylate deaminase -
BOO69_RS20675 109319..109795 + 477 WP_071974255.1 Lrp/AsnC ligand binding domain-containing protein -
BOO69_RS20680 109951..111543 + 1593 WP_071974256.1 gamma-glutamyltransferase -
BOO69_RS20685 111540..112928 + 1389 WP_071974257.1 M20 family metallopeptidase -
BOO69_RS20690 113043..113270 + 228 WP_071974344.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BOO69_RS20695 113260..113655 + 396 WP_071974258.1 PIN domain-containing protein Toxin
BOO69_RS20700 113773..114462 - 690 WP_071974259.1 TetR/AcrR family transcriptional regulator -
BOO69_RS20705 114598..115779 + 1182 WP_071974260.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..205668 205668


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-39)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14393.49 Da        Isoelectric Point: 4.4442

>T68667 WP_071974258.1 NZ_CP018080:113260-113655 [Sulfitobacter sp. AM1-D1]
MSAEFADTNVVLYLLDDGPKAERAEAILGQGPRISVQVLNEAMVNCRRKAGLSWEDTQAFLAGIQSLCPVEDLTVRTHVV
GRALAERYRLSVYDAMIVSAALIAGCTTLWSEDMHDGLLVEEQLRIVNPFS

Download         Length: 396 bp

>T68667 NZ_CP018080:113260-113655 [Sulfitobacter sp. AM1-D1]
ATGAGCGCTGAGTTCGCGGACACGAACGTTGTTCTCTATCTGCTGGACGACGGTCCCAAGGCCGAACGGGCCGAAGCCAT
CCTGGGGCAGGGGCCCCGGATCAGCGTTCAGGTTCTGAACGAAGCGATGGTCAATTGCCGGAGGAAAGCGGGGCTCAGCT
GGGAGGACACGCAGGCATTCCTCGCAGGAATCCAGTCCCTGTGCCCTGTAGAAGATCTGACGGTCCGGACCCACGTGGTG
GGCCGCGCCCTGGCGGAGAGATATCGGCTTTCCGTCTATGACGCGATGATCGTGTCTGCCGCCCTGATCGCCGGATGCAC
GACATTGTGGAGCGAGGACATGCACGACGGTTTGCTGGTGGAAGAGCAGTTGCGCATCGTCAATCCTTTCTCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8562.86 Da        Isoelectric Point: 10.8838

>AT68667 WP_071974344.1 NZ_CP018080:113043-113270 [Sulfitobacter sp. AM1-D1]
MQVAKWGNSLAVRLPADLVRELGLKEGDQIDLVKDEGTVFVRRQPRADEILQGLRRFRGKLPKDARLSRDAAHER

Download         Length: 228 bp

>AT68667 NZ_CP018080:113043-113270 [Sulfitobacter sp. AM1-D1]
ATGCAAGTTGCGAAATGGGGAAATTCCCTCGCGGTCCGGCTGCCTGCCGACCTTGTCCGGGAACTGGGGCTGAAGGAGGG
CGACCAGATCGACCTGGTGAAGGACGAAGGCACCGTGTTTGTCCGCCGTCAGCCGCGCGCCGATGAAATCCTGCAAGGTC
TGCGGCGGTTCCGGGGCAAGCTGCCCAAGGACGCGCGCCTGAGCCGCGACGCCGCGCATGAGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0WNY2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0WNT7

References