Detailed information of TA system TA068666

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 47795..48356
• Replicon: plasmid unnamed2
• Accession: NZ_CP018078
• Organism: Sulfitobacter sp. AM1-D1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A917AH87
• Locus tag: BOO69_RS19840
• Protein ID: WP_071974127.1
• Coordinates: 47795..48070 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1N7QLX2
• Locus tag: BOO69_RS19845
• Protein ID: WP_044353023.1
• Coordinates: 48057..48356 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOO69_RS19830	42918..43304	-	387	WP_071974125.1	hypothetical protein	-
BOO69_RS19835	43426..47688	-	4263	WP_071974126.1	strawberry notch family protein	-
BOO69_RS19840	47795..48070	-	276	WP_071974127.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
BOO69_RS19845	48057..48356	-	300	WP_044353023.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
BOO69_RS19850	48461..49117	-	657	WP_071974128.1	hypothetical protein	-
BOO69_RS19855	49117..49710	-	594	WP_071974129.1	regulator	-
BOO69_RS19860	49785..51767	-	1983	WP_071974130.1	ParB/RepB/Spo0J family partition protein	-
BOO69_RS19865	52233..53264	-	1032	WP_071972316.1	IS110 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..95272	95272

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-54)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10388.92 Da
• Isoelectric Point: 4.5837

>T68666 WP_071974127.1 NZ_CP018078:c48070-47795 [Sulfitobacter sp. AM1-D1]
MPNLEWKATAIADLLAIIDYISDDNPDAAQVLKDEIEHKTSLLPERPQMYRAGRVDGTREMVVRPNYIVVYAESPEMVTI
LRVLHAAQQWP

Nucleotide

• Length: 276 bp

>T68666 NZ_CP018078:c48070-47795 [Sulfitobacter sp. AM1-D1]
TTGCCAAATCTTGAATGGAAAGCCACGGCCATCGCCGACTTGTTGGCAATCATTGACTACATCTCTGACGACAACCCGGA
TGCCGCCCAAGTTCTCAAAGACGAGATTGAACACAAGACGTCCCTCCTTCCAGAACGCCCTCAGATGTACCGCGCGGGCC
GTGTGGACGGGACTAGGGAGATGGTTGTTCGGCCAAACTACATCGTGGTTTATGCTGAAAGCCCTGAGATGGTGACCATT
TTGCGCGTACTTCATGCTGCGCAGCAGTGGCCATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10462.91 Da
• Isoelectric Point: 5.6448

>AT68666 WP_044353023.1 NZ_CP018078:c48356-48057 [Sulfitobacter sp. AM1-D1]
MPAQTSMLHVRVDDQLKAQASDALAGVGLTLSDAVRILLTRVAAEGGLPAGLTADPDAYDAWFRAKVQEALDDPRPTTPH
AKAMQDAQALIDGKRLAKS

Nucleotide

• Length: 300 bp

>AT68666 NZ_CP018078:c48356-48057 [Sulfitobacter sp. AM1-D1]
ATGCCTGCCCAAACATCCATGCTTCATGTTCGTGTTGACGATCAGCTGAAAGCACAGGCTTCGGACGCACTTGCGGGCGT
CGGTCTGACGCTCTCCGATGCGGTGCGTATTCTTCTGACCCGCGTGGCCGCAGAAGGCGGATTGCCTGCCGGATTGACCG
CTGATCCGGATGCCTATGATGCCTGGTTCCGGGCGAAGGTACAGGAAGCGCTGGACGATCCAAGGCCCACAACGCCCCAT
GCCAAGGCGATGCAAGACGCCCAGGCATTGATTGACGGGAAGCGCCTTGCCAAATCTTGA

Structures

Antitoxin

• AlphaFold DB: A0A1N7QLX2