Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 1981447..1982399 Replicon chromosome
Accession NZ_CP018063
Organism Rhodococcus sp. 2G

Toxin (Protein)


Gene name pezT Uniprot ID A0A1J0TP76
Locus tag BO226_RS09230 Protein ID WP_071935066.1
Coordinates 1981447..1982016 (-) Length 190 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A7M2XIK8
Locus tag BO226_RS09235 Protein ID WP_016696422.1
Coordinates 1982013..1982399 (-) Length 129 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BO226_RS09230 1981447..1982016 - 570 WP_071935066.1 zeta toxin family protein Toxin
BO226_RS09235 1982013..1982399 - 387 WP_016696422.1 hypothetical protein Antitoxin
BO226_RS09240 1982607..1983677 + 1071 WP_197481790.1 class I SAM-dependent methyltransferase -
BO226_RS09245 1983747..1984112 + 366 WP_071935067.1 HNH endonuclease -
BO226_RS09250 1984155..1984673 - 519 WP_156895163.1 hypothetical protein -
BO226_RS09255 1985785..1986717 - 933 WP_071935069.1 TAXI family TRAP transporter solute-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-104)


Sequences

Toxin        


Download         Length: 190 a.a.        Molecular weight: 20571.75 Da        Isoelectric Point: 10.9607

>T68653 WP_071935066.1 NZ_CP018063:c1982016-1981447 [Rhodococcus sp. 2G]
MRRLDLIVGPNGSGKSTFVELSLAPLLPRSVFVNADVIARQRWPDRAEEMSYEAAQLAAAARDRLLRQGRSFIAETVFSH
PSKLELIDRAHEVGFTVVLHVMLVPEAMSVLRVQRRVASGGHAVPEDKIRARYRRLWPLVTEAIGRADQASVYDTASGTP
VVVARFAGGVPVGAVRWPGWAPAALTGLG

Download         Length: 570 bp

>T68653 NZ_CP018063:c1982016-1981447 [Rhodococcus sp. 2G]
ATGAGGCGTCTGGATCTGATCGTCGGTCCCAACGGTTCCGGCAAGTCGACGTTCGTCGAGTTGTCCCTCGCTCCCCTGCT
GCCGCGCAGCGTGTTCGTCAATGCGGATGTGATCGCGCGGCAGCGCTGGCCCGACCGGGCGGAGGAGATGTCGTACGAGG
CGGCGCAACTCGCCGCGGCGGCGCGGGACCGGTTGCTGCGGCAGGGCCGGTCGTTCATTGCGGAGACGGTGTTCTCGCAT
CCGTCGAAGCTGGAGTTGATCGACCGCGCGCACGAGGTGGGGTTCACGGTGGTGCTGCACGTGATGCTGGTGCCCGAGGC
GATGTCGGTGCTGCGTGTACAGCGCCGGGTGGCCTCCGGTGGGCATGCGGTGCCCGAGGACAAGATTCGGGCGCGCTATC
GGCGGTTGTGGCCGCTGGTGACCGAAGCGATCGGCCGCGCCGATCAGGCGTCGGTGTACGACACGGCGTCCGGGACCCCG
GTGGTGGTGGCGCGGTTCGCCGGCGGGGTGCCGGTGGGTGCGGTGCGCTGGCCGGGATGGGCGCCGGCGGCGCTCACCGG
GCTCGGCTGA

Antitoxin


Download         Length: 129 a.a.        Molecular weight: 14038.49 Da        Isoelectric Point: 4.7096

>AT68653 WP_016696422.1 NZ_CP018063:c1982399-1982013 [Rhodococcus sp. 2G]
MTSSTDKVTRFDAELVDSAIAEGGRQNRTGRQQLEYWARIGRAMTAHETASLHRVHEALAGTRELSELTAAEGRLFDAEI
DARLADGLARTDYAEVLAARGVTTVVLDDEGRLVEQRPDGSRRVLDDA

Download         Length: 387 bp

>AT68653 NZ_CP018063:c1982399-1982013 [Rhodococcus sp. 2G]
ATGACGTCATCCACAGACAAGGTCACCCGCTTCGACGCCGAACTCGTCGACAGCGCCATCGCCGAGGGCGGCCGCCAGAA
CCGCACCGGACGCCAGCAACTCGAATACTGGGCCCGCATCGGCCGCGCGATGACCGCCCACGAGACCGCCTCCCTGCACC
GGGTGCACGAGGCGCTGGCCGGGACACGGGAGCTGAGCGAGCTCACCGCCGCCGAGGGACGGCTGTTCGACGCGGAGATC
GATGCGCGCCTGGCGGACGGGCTGGCCCGCACCGACTACGCCGAGGTTCTCGCCGCGCGTGGGGTCACCACGGTGGTGCT
CGACGACGAAGGCCGGCTGGTCGAGCAGCGTCCCGACGGTAGTCGCCGGGTGCTCGACGACGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0TP76

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2XIK8

References