Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 3212927..3213423 Replicon chromosome
Accession NZ_CP018061
Organism Enterococcus mundtii strain DSM 4838

Toxin (Protein)


Gene name relE Uniprot ID A0A242KVG2
Locus tag EM4838_RS14990 Protein ID WP_071868044.1
Coordinates 3213157..3213423 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2K8TJA3
Locus tag EM4838_RS14985 Protein ID WP_071868045.1
Coordinates 3212927..3213160 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EM4838_RS14955 3208071..3208826 + 756 WP_071868047.1 ATP-binding cassette domain-containing protein -
EM4838_RS14960 3208848..3209801 + 954 WP_071868046.1 siderophore ABC transporter substrate-binding protein -
EM4838_RS14965 3210060..3210356 - 297 WP_010734416.1 hypothetical protein -
EM4838_RS14970 3210576..3211154 + 579 WP_010734415.1 GNAT family N-acetyltransferase -
EM4838_RS14975 3211202..3211561 + 360 WP_010734414.1 iron-sulfur cluster biosynthesis family protein -
EM4838_RS14980 3211580..3212476 + 897 WP_023518919.1 metallophosphoesterase -
EM4838_RS14985 3212927..3213160 + 234 WP_071868045.1 ribbon-helix-helix protein, CopG family Antitoxin
EM4838_RS14990 3213157..3213423 + 267 WP_071868044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EM4838_RS14995 3213834..3214568 - 735 WP_071868043.1 aquaporin family protein -
EM4838_RS15000 3215002..3216531 + 1530 WP_071868042.1 helix-turn-helix domain-containing protein -
EM4838_RS15005 3216521..3216742 + 222 WP_010734410.1 DUF2829 domain-containing protein -
EM4838_RS15010 3216739..3217500 + 762 WP_071868041.1 3-oxoacyl-ACP reductase -
EM4838_RS15015 3217529..3218176 + 648 WP_071868040.1 DUF998 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-63)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10454.18 Da        Isoelectric Point: 10.7105

>T68652 WP_071868044.1 NZ_CP018061:3213157-3213423 [Enterococcus mundtii]
MSYSVRTTPTFDRQIRKLDKFEATTILRWLHKQIEGTKNPRYTGKPLVGNYAGKWRYRIGNYRVITKIDDEKLIVLALEV
GHRKNIYL

Download         Length: 267 bp

>T68652 NZ_CP018061:3213157-3213423 [Enterococcus mundtii]
ATGAGCTACTCGGTAAGAACAACTCCTACCTTCGATAGGCAAATAAGAAAACTAGACAAATTCGAAGCAACAACTATATT
AAGATGGTTACATAAACAGATCGAAGGCACAAAAAATCCTAGATATACAGGTAAGCCACTTGTGGGGAACTACGCAGGTA
AATGGCGATACAGAATAGGAAATTATCGCGTCATTACAAAGATTGATGATGAAAAGTTGATTGTTTTAGCATTAGAAGTA
GGACATAGAAAAAATATATATCTATAG

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8825.00 Da        Isoelectric Point: 4.2984

>AT68652 WP_071868045.1 NZ_CP018061:3212927-3213160 [Enterococcus mundtii]
MATITVRVTEDEKKFLDEMAKFEGKSLSELLKTKTLDALEDAYDAKIGDLAYEEYLKDKKSNDLSVLLEEYDIGEKK

Download         Length: 234 bp

>AT68652 NZ_CP018061:3212927-3213160 [Enterococcus mundtii]
ATGGCAACAATTACAGTTCGTGTGACAGAAGATGAGAAAAAATTTTTGGATGAAATGGCTAAGTTTGAAGGAAAGAGTCT
CTCTGAATTACTTAAAACAAAAACATTAGATGCTTTAGAAGATGCGTATGATGCAAAGATAGGAGATTTAGCCTATGAAG
AGTATTTGAAAGATAAAAAATCAAATGATTTATCTGTTCTTTTAGAGGAGTATGATATAGGTGAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A242KVG2

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8TJA3

References