Detailed information of TA system TA068649

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 563537..564159
• Replicon: chromosome
• Accession: NZ_CP018059
• Organism: Moraxella catarrhalis strain CCRI-195ME

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1E9VU27
• Locus tag: MC195_RS02850
• Protein ID: WP_003660025.1
• Coordinates: 563977..564159 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A1E9VTZ2
• Locus tag: MC195_RS02845
• Protein ID: WP_003660026.1
• Coordinates: 563537..563944 (-)
• Length: 136 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MC195_RS02810	559507..559836	+	330	WP_080567272.1	phage tail protein	-
MC195_RS02815	559962..560222	-	261	WP_003663113.1	hypothetical protein	-
MC195_RS02820	560384..560935	+	552	WP_003663112.1	KilA-N domain-containing protein	-
MC195_RS02825	561078..561470	+	393	WP_081569809.1	hypothetical protein	-
MC195_RS02830	561569..562237	+	669	WP_003660031.1	phage minor tail protein L	-
MC195_RS02835	562439..562708	+	270	WP_013107943.1	hypothetical protein	-
MC195_RS02840	562766..563545	+	780	WP_081569810.1	C40 family peptidase	-
MC195_RS02845	563537..563944	-	408	WP_003660026.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MC195_RS02850	563977..564159	-	183	WP_003660025.1	type II toxin-antitoxin system HicA family toxin	Toxin
MC195_RS02855	564259..564870	+	612	WP_081569811.1	tail assembly protein	-
MC195_RS02860	564874..566376	+	1503	WP_065249113.1	host specificity protein J	-
MC195_RS09660	566425..566565	-	141	WP_003662311.1	hypothetical protein	-
MC195_RS02865	566711..567904	-	1194	WP_081569812.1	integrase family protein	-
MC195_RS02870	568130..568612	-	483	WP_003660020.1	acyl-CoA thioesterase	-
MC195_RS02875	568635..568955	-	321	WP_003660019.1	TusE/DsrC/DsvC family sulfur relay protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	531190..567904	36714

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6813.95 Da
• Isoelectric Point: 10.6682

>T68649 WP_003660025.1 NZ_CP018059:c564159-563977 [Moraxella catarrhalis]
MNSRQMIKLITDDGWYEVAVRGSHHHYKHPTKQGKVTIPHPKSDLPIGTVKQILKQAGLK

Nucleotide

• Length: 183 bp

>T68649 NZ_CP018059:c564159-563977 [Moraxella catarrhalis]
ATGAATAGCCGTCAAATGATTAAGCTAATCACTGATGACGGTTGGTATGAAGTTGCGGTGCGTGGCAGTCATCATCACTA
CAAACACCCAACCAAACAGGGCAAGGTAACCATACCTCACCCCAAGTCAGACTTACCAATCGGCACAGTTAAGCAAATCT
TAAAACAAGCTGGGTTAAAATAA

Antitoxin

Protein

• Length: 136 a.a.
• Molecular weight: 14907.99 Da
• Isoelectric Point: 4.4954

>AT68649 WP_003660026.1 NZ_CP018059:c563944-563537 [Moraxella catarrhalis]
MLYPIAIEKPVSTNECYGVIVPDIVGCFSAGDTVDEAVKNAYEAIVLHLDMLADDGEDIPQATDIAHHQENPDYQGMIWA
VVDIDLSAYMGKSEKINVTLPSRLIVKIDEKVKAHKSLYKSRSNYLAQLASRDLA

Nucleotide

• Length: 408 bp

>AT68649 NZ_CP018059:c563944-563537 [Moraxella catarrhalis]
ATGTTATATCCTATCGCCATTGAAAAGCCCGTCAGCACCAATGAGTGTTATGGCGTAATTGTACCTGATATTGTAGGCTG
TTTTAGTGCAGGCGATACAGTAGATGAGGCGGTTAAAAATGCCTATGAAGCCATTGTTTTGCATTTGGATATGTTGGCTG
ATGATGGTGAGGATATCCCTCAAGCGACCGATATTGCTCATCATCAAGAAAATCCTGATTATCAAGGTATGATTTGGGCG
GTGGTTGATATTGATTTATCCGCCTATATGGGCAAATCTGAAAAGATTAATGTTACCTTGCCAAGTCGCTTGATTGTCAA
AATTGACGAAAAGGTTAAAGCACACAAATCGCTATATAAGAGTCGTAGTAATTACCTAGCACAGCTTGCCAGTCGTGATT
TAGCCTAG

Structures

Toxin

• AlphaFold DB: A0A1E9VU27

Antitoxin

• AlphaFold DB: A0A1E9VTZ2