Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) doc-NpoA/Fic(toxin)
Location 3253714..3254994 Replicon chromosome
Accession NZ_CP018058
Organism Geobacillus thermocatenulatus strain KCTC 3921

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GT3921_RS16510 Protein ID WP_089113971.1
Coordinates 3253714..3254028 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name NpoA Uniprot ID -
Locus tag GT3921_RS16515 Protein ID WP_053915229.1
Coordinates 3254131..3254994 (+) Length 288 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GT3921_RS16495 3249302..3252712 + 3411 WP_089113970.1 methionine synthase -
GT3921_RS16500 3252874..3253293 - 420 WP_025951004.1 type II toxin-antitoxin system VapC family toxin -
GT3921_RS16505 3253318..3253611 - 294 WP_025951003.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
GT3921_RS16510 3253714..3254028 + 315 WP_089113971.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GT3921_RS16515 3254131..3254994 + 864 WP_053915229.1 SDR family oxidoreductase Antitoxin
GT3921_RS16520 3255119..3255802 + 684 WP_025951001.1 HAMP domain-containing histidine kinase -
GT3921_RS16525 3256099..3257442 - 1344 WP_025951000.1 aromatic acid/H+ symport family MFS transporter -
GT3921_RS16530 3257468..3258385 - 918 WP_089113972.1 NAD(P)-dependent oxidoreductase -
GT3921_RS16535 3258409..3259134 - 726 WP_089113973.1 4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase -
GT3921_RS16540 3259134..3259862 - 729 WP_089113974.1 PIG-L family deacetylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(28-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11945.78 Da        Isoelectric Point: 9.5080

>T68648 WP_089113971.1 NZ_CP018058:3253714-3254028 [Geobacillus thermocatenulatus]
MFPKFPKLLNSAVNRPKQSAFGQDADPTLWLKAAALYASLCQNHPFHNANKRTGFAAMKQFLWLNGYRLAAPEKEAEEYT
VKIVTDKPSIEEIAMWMETWAEKR

Download         Length: 315 bp

>T68648 NZ_CP018058:3253714-3254028 [Geobacillus thermocatenulatus]
ATGTTCCCCAAATTTCCGAAGCTGTTGAACAGCGCGGTCAACCGCCCGAAACAAAGCGCTTTCGGGCAGGACGCTGATCC
AACCCTTTGGCTGAAGGCGGCAGCGTTATACGCCAGCCTCTGCCAAAACCATCCGTTTCACAATGCCAATAAACGAACAG
GCTTTGCCGCCATGAAACAGTTTCTTTGGCTAAACGGCTATCGCCTTGCCGCTCCGGAAAAAGAAGCAGAAGAATATACC
GTGAAAATCGTAACCGATAAACCATCGATTGAGGAAATCGCGATGTGGATGGAAACGTGGGCGGAAAAAAGATGA

Antitoxin


Download         Length: 288 a.a.        Molecular weight: 30868.09 Da        Isoelectric Point: 6.7432

>AT68648 WP_053915229.1 NZ_CP018058:3254131-3254994 [Geobacillus thermocatenulatus]
MVTKQQTTLPPQHQTRQPGLQTEMNPQPVTIKDTYQGSGKLKNKTAIISGGDSGIGRAVAVHFAKEGADVAILYLNEHED
AEETKRLVEQEGRRCLAIAGDIGDEAFCKEAVKQTIEAFGKLDIVVNNAAEQHPQPNFLNITAEQLEKTFRTNVFGCFFL
TKAALPHLKSGSAIINTASITAYEGNEQLIDYSATKGAIVAFTRSLAKALVGQGIRVNGVAPGPIWTPLIPSTFKSEQVA
TFGANTPMKRPGQPCEVAPCYVFLASDESSYMTGQMLHVDGGKFVSG

Download         Length: 864 bp

>AT68648 NZ_CP018058:3254131-3254994 [Geobacillus thermocatenulatus]
ATGGTCACAAAGCAACAAACGACACTGCCCCCGCAGCACCAAACGCGCCAGCCCGGCCTGCAAACGGAGATGAACCCGCA
GCCGGTCACCATCAAAGACACGTATCAAGGAAGCGGCAAGCTCAAAAACAAAACCGCCATCATCAGCGGCGGCGACAGCG
GCATCGGCCGGGCGGTCGCGGTCCATTTTGCCAAGGAAGGAGCCGATGTGGCGATTCTCTATCTCAACGAACATGAAGAC
GCCGAAGAAACGAAACGGCTCGTCGAGCAGGAAGGAAGACGGTGCCTGGCCATTGCGGGAGACATTGGCGATGAAGCGTT
TTGCAAAGAGGCGGTGAAACAGACGATCGAAGCGTTCGGCAAGCTCGATATCGTCGTCAATAACGCCGCCGAGCAGCACC
CGCAGCCGAATTTTCTCAACATTACCGCCGAGCAGCTGGAAAAAACGTTTCGCACGAACGTGTTCGGCTGCTTTTTCCTA
ACGAAAGCGGCGCTCCCGCACTTAAAAAGCGGAAGCGCGATTATTAACACCGCTTCGATCACCGCCTACGAAGGAAACGA
GCAACTCATCGACTACTCGGCGACAAAAGGGGCGATCGTCGCCTTCACCCGCTCGCTCGCCAAAGCGCTCGTCGGCCAAG
GCATTCGCGTCAACGGCGTCGCCCCAGGCCCGATTTGGACGCCGCTCATCCCGTCGACGTTCAAAAGCGAGCAAGTCGCC
ACATTCGGTGCCAACACGCCGATGAAACGGCCCGGCCAGCCGTGCGAAGTCGCTCCGTGCTACGTCTTTTTGGCGAGCGA
CGAATCGTCGTACATGACCGGGCAAATGCTTCACGTCGACGGCGGAAAGTTCGTCAGCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References