Detailed information of TA system TA068645

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1479042..1479532
• Replicon: chromosome
• Accession: NZ_CP018057
• Organism: Exiguobacterium sp. ZWU0009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L985_RS07615
• Protein ID: WP_047394265.1
• Coordinates: 1479042..1479311 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A031ILR5
• Locus tag: L985_RS07620
• Protein ID: WP_026829710.1
• Coordinates: 1479308..1479532 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L985_RS07595	1474504..1474830	+	327	WP_071908772.1	four-helix bundle copper-binding protein	-
L985_RS07600	1475150..1475830	+	681	WP_047394277.1	response regulator transcription factor	-
L985_RS07605	1475868..1476293	-	426	WP_148662059.1	hypothetical protein	-
L985_RS07610	1476804..1478810	+	2007	WP_047394268.1	copper-translocating P-type ATPase	-
L985_RS07615	1479042..1479311	-	270	WP_047394265.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L985_RS07620	1479308..1479532	-	225	WP_026829710.1	ribbon-helix-helix protein, CopG family	Antitoxin
L985_RS07625	1480056..1480700	+	645	WP_047394298.1	hypothetical protein	-
L985_RS07630	1480672..1481355	+	684	WP_047394256.1	hypothetical protein	-
L985_RS16875	1481456..1481653	+	198	Protein_1442	hypothetical protein	-
L985_RS07635	1481982..1483253	+	1272	WP_047394253.1	serine/threonine transporter SstT	-
L985_RS07640	1483330..1483716	-	387	WP_047394249.1	hypothetical protein	-
L985_RS07645	1483744..1484220	-	477	WP_047394244.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10459.10 Da
• Isoelectric Point: 10.3966

>T68645 WP_047394265.1 NZ_CP018057:c1479311-1479042 [Exiguobacterium sp. ZWU0009]
MTAYSVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Nucleotide

• Length: 270 bp

>T68645 NZ_CP018057:c1479311-1479042 [Exiguobacterium sp. ZWU0009]
ATGACGGCATATTCGGTAGAGTTTGAGCGCGGAGCTCAAAAGTCTCTCAAGAAGATGGACCCACAACAAGCGCGGATCAT
CATGTCCTGGATCAAGAAGAATCTGGTCGGGACGGATGATCCGCGTCGTCATGGGAAAGGACTGGTCTCGAATCGTTCTG
GTGAATGGCGGTATCGCATCGGTGACTATCGTCTGATTGCTGACATCCAGGATGAAAAAGTCGTGATCTTAATTCTTGAA
ATCGGTCATCGTCGTGACATTTATAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8599.76 Da
• Isoelectric Point: 4.5010

>AT68645 WP_026829710.1 NZ_CP018057:c1479532-1479308 [Exiguobacterium sp. ZWU0009]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSMAAHRKKSEAISFDDMMKELDLE

Nucleotide

• Length: 225 bp

>AT68645 NZ_CP018057:c1479532-1479308 [Exiguobacterium sp. ZWU0009]
ATGAGTACCATTTCCGTACGTCTGGATGATCAGGATACACGACTTATCAAGGAATATGCGAAGGCAAAGAACATCACGAT
TTCTACACTCGTTCGCGATGCCGTCCTCGACCGTATCGAAGACGAAATCGATTTGCAACTCTATCATGATTCCATGGCAG
CACACCGTAAAAAATCAGAAGCGATATCTTTCGACGACATGATGAAGGAACTTGATTTAGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A031ILR5