Detailed information of TA system TA068644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1459561..1460051
• Replicon: chromosome
• Accession: NZ_CP018057
• Organism: Exiguobacterium sp. ZWU0009

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0V8GC58
• Locus tag: L985_RS07500
• Protein ID: WP_047395636.1
• Coordinates: 1459561..1459830 (-)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L985_RS07505
• Protein ID: WP_047395634.1
• Coordinates: 1459827..1460051 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L985_RS16865	1455305..1455430	-	126	WP_148662058.1	hypothetical protein	-
L985_RS07485	1455618..1456616	-	999	Protein_1413	Fic family protein	-
L985_RS07490	1456945..1457784	-	840	WP_047395643.1	helix-turn-helix transcriptional regulator	-
L985_RS07495	1457906..1459144	+	1239	WP_047395639.1	beta-ketoacyl-ACP synthase II	-
L985_RS07500	1459561..1459830	-	270	WP_047395636.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L985_RS07505	1459827..1460051	-	225	WP_047395634.1	ribbon-helix-helix protein, CopG family	Antitoxin
L985_RS07510	1460249..1460803	-	555	WP_047395631.1	hypothetical protein	-
L985_RS07515	1460855..1461346	-	492	WP_047395628.1	hypothetical protein	-
L985_RS07520	1461343..1461831	-	489	WP_047395625.1	copper resistance protein CopC	-
L985_RS07525	1462035..1462355	+	321	WP_035413106.1	metalloregulator ArsR/SmtB family transcription factor	-
L985_RS16870	1462358..1463482	+	1125	WP_148662018.1	cation transporter	-
L985_RS07540	1463382..1463894	+	513	WP_071908767.1	cation-translocating P-type ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-88)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10457.13 Da
• Isoelectric Point: 10.5148

>T68644 WP_047395636.1 NZ_CP018057:c1459830-1459561 [Exiguobacterium sp. ZWU0009]
MTAFTVEFERGAQKSLKKMDPQQARIIMSWIKKNLVGTDDPRRHGKGLVSNRSGEWRYRIGDYRLIADIQDEKVVILILE
IGHRRDIYK

Nucleotide

• Length: 270 bp

>T68644 NZ_CP018057:c1459830-1459561 [Exiguobacterium sp. ZWU0009]
ATGACAGCATTTACGGTAGAGTTTGAGCGCGGAGCTCAAAAGTCTCTCAAGAAGATGGATCCTCAACAAGCGCGGATCAT
CATGTCCTGGATCAAGAAGAATCTGGTCGGGACGGATGATCCGCGTCGTCATGGAAAAGGACTGGTCTCGAATCGCTCGG
GTGAATGGCGGTATCGCATCGGTGATTATCGTCTGATTGCTGACATCCAGGATGAGAAAGTCGTGATATTGATTCTTGAG
ATTGGACATCGTCGGGATATCTATAAATAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8581.73 Da
• Isoelectric Point: 4.5010

>AT68644 WP_047395634.1 NZ_CP018057:c1460051-1459827 [Exiguobacterium sp. ZWU0009]
MSTISVRLDDQDTRLIKEYAKAKNITISTLVRDAVLDRIEDEIDLQLYHDSIAAHRKKSEAISFDDMMKELDLE

Nucleotide

• Length: 225 bp

>AT68644 NZ_CP018057:c1460051-1459827 [Exiguobacterium sp. ZWU0009]
ATGAGTACCATTTCCGTACGTCTGGATGACCAGGATACACGACTCATCAAAGAATATGCGAAGGCAAAAAACATCACGAT
TTCTACACTCGTTCGCGATGCCGTCCTCGACCGCATCGAAGACGAAATCGATTTACAACTCTATCATGATTCGATAGCAG
CACACCGTAAAAAATCAGAAGCGATCTCTTTCGACGATATGATGAAGGAACTTGATTTAGAATGA

Structures

Toxin

• AlphaFold DB: A0A0V8GC58