Detailed information of TA system TA068643

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4641951..4642608
• Replicon: chromosome
• Accession: NZ_CP018056
• Organism: Klebsiella pneumoniae subsp. pneumoniae strain H11

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: KPH11_RS23145
• Protein ID: WP_040245400.1
• Coordinates: 4642198..4642608 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: KPH11_RS23140
• Protein ID: WP_002916312.1
• Coordinates: 4641951..4642217 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KPH11_RS23115	4637107..4638540	-	1434	WP_099761700.1	6-phospho-beta-glucosidase BglA	-
KPH11_RS23120	4638659..4639387	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
KPH11_RS23125	4639437..4639748	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
KPH11_RS23130	4639912..4640571	+	660	WP_002916317.1	hemolysin III family protein	-
KPH11_RS23135	4640722..4641705	-	984	WP_099761701.1	tRNA-modifying protein YgfZ	-
KPH11_RS23140	4641951..4642217	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
KPH11_RS23145	4642198..4642608	+	411	WP_040245400.1	protein YgfX	Toxin
KPH11_RS23150	4642615..4643136	-	522	WP_002916308.1	flavodoxin FldB	-
KPH11_RS23155	4643237..4644133	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
KPH11_RS23160	4644156..4644869	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
KPH11_RS23165	4644875..4646608	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16035.83 Da
• Isoelectric Point: 11.4778

>T68643 WP_040245400.1 NZ_CP018056:4642198-4642608 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDSRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T68643 NZ_CP018056:4642198-4642608 [Klebsiella pneumoniae subsp. pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT68643 WP_002916312.1 NZ_CP018056:4641951-4642217 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT68643 NZ_CP018056:4641951-4642217 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41