Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2538420..2539039 Replicon chromosome
Accession NZ_CP018056
Organism Klebsiella pneumoniae subsp. pneumoniae strain H11

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KPH11_RS12595 Protein ID WP_002892050.1
Coordinates 2538821..2539039 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KPH11_RS12590 Protein ID WP_002892066.1
Coordinates 2538420..2538794 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPH11_RS12580 2533572..2534765 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KPH11_RS12585 2534788..2537934 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KPH11_RS12590 2538420..2538794 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KPH11_RS12595 2538821..2539039 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
KPH11_RS12600 2539198..2539764 + 567 WP_002892030.1 maltose O-acetyltransferase -
KPH11_RS27015 2539736..2539876 - 141 WP_032410934.1 hypothetical protein -
KPH11_RS12605 2539897..2540367 + 471 WP_040187972.1 YlaC family protein -
KPH11_RS12610 2540342..2540821 - 480 WP_086556125.1 GntR family transcriptional regulator -
KPH11_RS12615 2540922..2541620 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
KPH11_RS12620 2541617..2541757 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KPH11_RS12625 2541757..2542020 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -
KPH11_RS12630 2542136..2543206 - 1071 WP_002892007.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T68637 WP_002892050.1 NZ_CP018056:2538821-2539039 [Klebsiella pneumoniae subsp. pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T68637 NZ_CP018056:2538821-2539039 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAACTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT68637 WP_002892066.1 NZ_CP018056:2538420-2538794 [Klebsiella pneumoniae subsp. pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT68637 NZ_CP018056:2538420-2538794 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References