68625

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 4931167..4932209 Replicon chromosome
Accession NZ_CP018049
Organism Pseudomonas orientalis strain F9

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag BOP93_RS22225 Protein ID WP_104504675.1
Coordinates 4931167..4931742 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID A0A1B5D4Q5
Locus tag BOP93_RS22230 Protein ID WP_065892392.1
Coordinates 4931739..4932209 (-) Length 157 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOP93_RS22185 4926769..4927092 + 324 WP_104504667.1 hypothetical protein -
BOP93_RS22190 4927190..4927564 + 375 WP_104504668.1 cupin domain-containing protein -
BOP93_RS22195 4927640..4928110 + 471 WP_104504669.1 hypothetical protein -
BOP93_RS22200 4928113..4928397 - 285 WP_104504670.1 hypothetical protein -
BOP93_RS22205 4928428..4929324 - 897 WP_104504671.1 hypothetical protein -
BOP93_RS22210 4929542..4929871 + 330 WP_104504672.1 hypothetical protein -
BOP93_RS22215 4929879..4930514 - 636 WP_104504673.1 LysE family translocator -
BOP93_RS22220 4930672..4931043 + 372 WP_104504674.1 PH domain-containing protein -
BOP93_RS22225 4931167..4931742 - 576 WP_104504675.1 PIN domain-containing protein Toxin
BOP93_RS22230 4931739..4932209 - 471 WP_065892392.1 helix-turn-helix domain-containing protein Antitoxin
BOP93_RS22235 4932396..4933550 + 1155 WP_104504676.1 S-type pyocin domain-containing protein -
BOP93_RS22240 4933558..4933815 + 258 WP_065936612.1 colicin transporter -
BOP93_RS22245 4934240..4934614 - 375 WP_104504677.1 cytochrome c family protein -
BOP93_RS22250 4934789..4935169 + 381 WP_065885090.1 response regulator -
BOP93_RS22255 4935366..4935980 + 615 WP_104504678.1 biliverdin-producing heme oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4907430..4933815 26385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-115)

Antitoxin

Helix-turn-helix domain, group 17

(84-132)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21672.94 Da        Isoelectric Point: 4.8707

>T68625 WP_104504675.1 NZ_CP018049:c4931742-4931167 [Pseudomonas orientalis]
MRCSPFTAVYDACVLYPAALRDLLMWLGLSGLYRARWTSQIHEEWKRNVLKNRPDLTSEQVDSTSTMMDKAIPDGLVTGY
EELCSSLDLPDPDDRHVLAAAIRSKAEVIVTFNLKDFPSHILAAYDIEPMHPDDFISDLWDLDQAAVLAAAQKQRRALKR
PPMDTQSYLEMLMRQGLVQTSKVLGPYEVML

Download         Length: 576 bp

>T68625 NZ_CP018049:c4931742-4931167 [Pseudomonas orientalis]
ATGAGGTGTTCGCCGTTCACTGCGGTATACGATGCTTGTGTTCTTTACCCGGCAGCACTCCGGGATCTGTTGATGTGGCT
GGGATTGTCTGGTCTGTATCGAGCGCGATGGACCAGCCAGATCCATGAAGAGTGGAAGCGCAATGTGCTAAAAAATCGCC
CCGACCTTACTTCGGAGCAAGTGGATAGCACTTCAACGATGATGGACAAGGCTATACCTGACGGGCTGGTGACAGGGTAT
GAGGAGTTATGTTCGAGCCTGGATTTGCCCGATCCTGATGATCGTCACGTACTGGCGGCGGCGATTCGTAGTAAGGCGGA
GGTCATCGTTACTTTCAACTTGAAAGACTTCCCATCGCATATCTTGGCTGCTTATGACATTGAGCCAATGCACCCGGATG
ACTTTATCTCGGATCTTTGGGATTTGGATCAGGCAGCAGTACTGGCCGCGGCACAGAAGCAGAGGCGAGCGTTGAAGCGG
CCGCCAATGGATACGCAGAGTTATCTGGAGATGTTGATGCGTCAAGGGCTGGTGCAGACAAGTAAGGTGCTTGGGCCTTA
TGAGGTGATGCTGTAG

Antitoxin


Download         Length: 157 a.a.        Molecular weight: 17416.13 Da        Isoelectric Point: 6.0061

>AT68625 WP_065892392.1 NZ_CP018049:c4932209-4931739 [Pseudomonas orientalis]
MITPHLPKTIPPLEKEVEAAVQGQRELASLLSTKFDTQRIDIFDKEDKPHSLVLPTSALRLLVDILGELALGNAVKVVPV
HAELTSQEAADLLNVSRPHLVKMLEEGAIPFTKTGRHRRIRFSDLMAFKQQRDAESQEAMEALVRQAQELGMGYDL

Download         Length: 471 bp

>AT68625 NZ_CP018049:c4932209-4931739 [Pseudomonas orientalis]
ATGATCACCCCGCACCTCCCTAAAACAATTCCTCCGCTGGAAAAGGAAGTCGAAGCCGCCGTTCAGGGCCAGCGCGAATT
GGCCTCATTGCTGTCGACCAAATTCGACACTCAACGCATCGATATCTTCGACAAAGAAGACAAACCCCACTCCCTTGTAC
TCCCCACATCCGCGCTACGTCTGCTGGTTGATATTTTGGGTGAGCTGGCGCTGGGCAATGCCGTCAAGGTTGTACCCGTC
CATGCTGAGTTGACCTCCCAGGAAGCTGCCGACCTGCTCAACGTTTCACGCCCGCACCTGGTGAAGATGCTGGAAGAAGG
CGCCATTCCTTTTACGAAGACGGGTCGCCATCGGCGTATCCGGTTTTCAGATTTGATGGCGTTTAAACAGCAGCGCGATG
CAGAAAGCCAAGAGGCGATGGAGGCGTTGGTACGGCAGGCTCAGGAGCTAGGTATGGGGTATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1B5D4Q5

References