Detailed information of TA system TA068624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4575023..4575587
• Replicon: chromosome
• Accession: NZ_CP018049
• Organism: Pseudomonas orientalis strain F9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: BOP93_RS20560
• Protein ID: WP_104505336.1
• Coordinates: 4575023..4575304 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A1B5E756
• Locus tag: BOP93_RS20565
• Protein ID: WP_065894994.1
• Coordinates: 4575300..4575587 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOP93_RS20540	4570622..4572439	-	1818	WP_104504454.1	hypothetical protein	-
BOP93_RS20545	4572784..4573362	+	579	WP_104504455.1	Bro-N domain-containing protein	-
BOP93_RS20550	4573462..4574178	+	717	WP_104504456.1	HNH endonuclease	-
BOP93_RS20555	4574252..4574899	+	648	WP_065887762.1	HAD-IB family hydrolase	-
BOP93_RS20560	4575023..4575304	-	282	WP_104505336.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
BOP93_RS20565	4575300..4575587	-	288	WP_065894994.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BOP93_RS20570	4575844..4576803	-	960	WP_104504457.1	LysR family transcriptional regulator	-
BOP93_RS20575	4576997..4578424	+	1428	WP_104504458.1	argininosuccinate lyase	-
BOP93_RS20580	4578570..4579448	+	879	WP_104504459.1	amino acid ABC transporter permease	-
BOP93_RS20585	4579474..4580238	+	765	WP_104504460.1	amino acid ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-77)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10944.76 Da
• Isoelectric Point: 10.3141

>T68624 WP_104505336.1 NZ_CP018049:c4575304-4575023 [Pseudomonas orientalis]
IEFSIEWDPKALKELKKLDGTIRHQFLRKLQERQDHPRVPADALYGMKDCYKIKLRGAGFRLVYRVEDDRIVILVLAVGK
RERSTVYDSAKSR

Nucleotide

• Length: 282 bp

>T68624 NZ_CP018049:c4575304-4575023 [Pseudomonas orientalis]
ATTGAGTTTAGTATTGAGTGGGATCCGAAGGCGTTAAAGGAACTCAAGAAACTGGACGGTACAATTCGTCATCAGTTTTT
GCGCAAACTTCAGGAGCGCCAAGATCACCCGCGGGTTCCAGCTGACGCGCTTTATGGAATGAAGGATTGCTACAAAATCA
AATTACGTGGTGCCGGCTTTCGGCTGGTCTACCGTGTTGAGGACGATCGAATAGTCATCCTCGTATTAGCGGTGGGTAAG
CGGGAACGTAGCACTGTCTACGATTCGGCCAAGAGCCGATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10244.76 Da
• Isoelectric Point: 4.3557

>AT68624 WP_065894994.1 NZ_CP018049:c4575587-4575300 [Pseudomonas orientalis]
MQLVLADVAVSVSELKKNPSSVMNGANGSAVAVLNHNRVMGYMVPASVYEAMVERLDELELVQLVKERLDAKEAPIRVSL
DELIAEAEADIANGH

Nucleotide

• Length: 288 bp

>AT68624 NZ_CP018049:c4575587-4575300 [Pseudomonas orientalis]
ATGCAACTTGTTTTGGCTGACGTGGCCGTCAGCGTATCCGAACTCAAAAAGAACCCTTCATCCGTCATGAACGGAGCCAA
CGGCTCGGCGGTGGCTGTCCTCAACCATAATCGCGTGATGGGTTATATGGTCCCGGCTAGCGTATACGAGGCGATGGTTG
AGCGCCTTGATGAGCTGGAACTGGTGCAATTGGTCAAGGAGAGGCTGGACGCCAAGGAGGCACCGATTCGGGTGTCCCTT
GATGAGCTGATTGCTGAGGCAGAGGCGGATATCGCCAATGGGCATTGA

Structures

Antitoxin

• AlphaFold DB: A0A1B5E756