Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 5113166..5113800 Replicon chromosome
Accession NZ_CP018047
Organism Streptomyces niveus strain SCSIO 3406

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BBN63_RS22445 Protein ID WP_078077087.1
Coordinates 5113166..5113582 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag BBN63_RS22450 Protein ID WP_078077088.1
Coordinates 5113579..5113800 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BBN63_RS22420 5108422..5109159 + 738 WP_078077083.1 hypothetical protein -
BBN63_RS22425 5109250..5111370 + 2121 WP_078077084.1 glycosyltransferase -
BBN63_RS22430 5111367..5112686 + 1320 WP_078077085.1 acyltransferase -
BBN63_RS22440 5113004..5113153 + 150 Protein_4413 MBL fold metallo-hydrolase -
BBN63_RS22445 5113166..5113582 - 417 WP_078077087.1 PIN domain-containing protein Toxin
BBN63_RS22450 5113579..5113800 - 222 WP_078077088.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BBN63_RS22455 5113978..5115384 + 1407 WP_078077089.1 NarK/NasA family nitrate transporter -
BBN63_RS22460 5115500..5116642 + 1143 WP_078077090.1 uroporphyrinogen-III synthase -
BBN63_RS22465 5116722..5117249 + 528 WP_078077091.1 GNAT family N-acetyltransferase -
BBN63_RS22470 5117411..5118013 + 603 WP_078077092.1 ABATE domain-containing protein -
BBN63_RS22475 5118173..5118760 + 588 WP_078079742.1 sigma-70 family RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(4-48)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 16015.16 Da        Isoelectric Point: 7.1173

>T68619 WP_078077087.1 NZ_CP018047:c5113582-5113166 [Streptomyces niveus]
VIRYLIDSSAVWRILRDKELRAPWSEAISGGAVGSCQPQRVEFKRSARHVDEYDRMTDMFAELHPDVPVPKNPWPWIETA
QYRLAQRGRHQALSVTDWLICATAAHRDVIVLHDDNDFRSAASLLPDLRERRIHEIPH

Download         Length: 417 bp

>T68619 NZ_CP018047:c5113582-5113166 [Streptomyces niveus]
GTGATTCGCTATCTGATCGATTCGTCCGCCGTGTGGCGGATCCTTCGCGACAAGGAACTGCGCGCTCCCTGGAGCGAGGC
GATCAGCGGCGGGGCGGTCGGGTCCTGCCAGCCGCAGCGGGTGGAGTTCAAGCGGTCCGCACGGCACGTCGACGAGTACG
ACCGCATGACGGACATGTTCGCCGAGCTGCACCCCGACGTCCCGGTACCGAAGAATCCCTGGCCCTGGATCGAGACCGCC
CAGTACCGGCTGGCTCAGCGAGGCCGGCATCAGGCTCTCTCGGTGACCGACTGGCTGATCTGCGCGACAGCGGCGCACCG
CGACGTGATCGTCCTGCACGACGACAACGATTTCAGGTCCGCCGCCTCGCTCCTGCCCGACCTGCGTGAACGCCGTATCC
ACGAAATCCCTCACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8281.23 Da        Isoelectric Point: 7.0145

>AT68619 WP_078077088.1 NZ_CP018047:c5113800-5113579 [Streptomyces niveus]
VSLTTIDLDDEALAAAMRVSGIRTKKEAVNTALREFTARHRRIAALEEYASLAEGWDYESWERQRASEKRGGR

Download         Length: 222 bp

>AT68619 NZ_CP018047:c5113800-5113579 [Streptomyces niveus]
GTGAGCCTGACGACGATCGACCTCGATGACGAAGCGCTGGCCGCCGCGATGCGCGTGTCCGGCATAAGGACGAAGAAGGA
AGCGGTGAACACCGCTCTGCGCGAGTTCACCGCCCGGCACCGTCGCATCGCGGCGCTGGAGGAGTACGCCTCGCTCGCCG
AGGGCTGGGACTACGAGTCGTGGGAGCGGCAGCGTGCCTCCGAGAAGCGGGGCGGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References