Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 5595408..5596064 Replicon chromosome
Accession NZ_CP018043
Organism Mycobacterium sp. WY10

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A1J0UFA4
Locus tag BOH72_RS27530 Protein ID WP_071949327.1
Coordinates 5595618..5596064 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A1J0UF69
Locus tag BOH72_RS27525 Protein ID WP_071949325.1
Coordinates 5595408..5595614 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOH72_RS27515 5591422..5593008 + 1587 WP_071949323.1 serine hydrolase -
BOH72_RS27520 5593005..5595404 + 2400 WP_071949324.1 HAD-IC family P-type ATPase -
BOH72_RS27525 5595408..5595614 + 207 WP_071949325.1 antitoxin Antitoxin
BOH72_RS27530 5595618..5596064 + 447 WP_071949327.1 SRPBCC family protein Toxin
BOH72_RS27535 5596068..5596451 - 384 WP_156909891.1 hypothetical protein -
BOH72_RS27540 5596592..5596819 + 228 WP_071949330.1 hypothetical protein -
BOH72_RS27545 5596821..5597480 - 660 WP_071949331.1 response regulator transcription factor -
BOH72_RS27550 5597589..5598476 + 888 WP_071949333.1 amidohydrolase family protein -
BOH72_RS27555 5598473..5599357 - 885 WP_071950322.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(9-55)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16061.74 Da        Isoelectric Point: 10.1635

>T68617 WP_071949327.1 NZ_CP018043:5595618-5596064 [Mycobacterium sp. WY10]
MAKLSVSVDVPLPPEQAWQHASDLSRYKDWLTIHRVWRSKLPDTLEKGTVVESIVEVKGMPNRVKWEIVHFKAPEAMTLN
GAGVGGVKVKLIGKVRAHDKDPNSSVVTMDVHLGGAALFGPIGMVVAGALKGDIKESLNRFVTVFAPS

Download         Length: 447 bp

>T68617 NZ_CP018043:5595618-5596064 [Mycobacterium sp. WY10]
ATGGCGAAACTCTCAGTCTCCGTTGACGTTCCACTTCCACCAGAGCAGGCCTGGCAGCACGCCTCGGACCTCTCGCGCTA
CAAGGACTGGCTGACCATCCACCGGGTGTGGCGCTCCAAACTGCCCGACACCCTCGAGAAGGGCACCGTCGTGGAGTCCA
TCGTCGAGGTCAAGGGCATGCCCAACCGGGTGAAGTGGGAGATCGTCCACTTCAAGGCCCCCGAGGCCATGACGCTCAAT
GGCGCCGGCGTCGGCGGGGTGAAGGTCAAGCTGATCGGCAAGGTGCGGGCCCACGACAAGGACCCCAACAGTTCGGTGGT
GACCATGGACGTCCATCTGGGCGGTGCGGCGCTGTTCGGGCCGATCGGCATGGTCGTGGCCGGTGCGCTCAAGGGCGACA
TCAAGGAGTCGCTGAACCGCTTTGTGACGGTATTCGCGCCGTCGTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7374.13 Da        Isoelectric Point: 5.0152

>AT68617 WP_071949325.1 NZ_CP018043:5595408-5595614 [Mycobacterium sp. WY10]
MGFLDKALGKTKEVLGSNADKVEQAIDKAGDIIDQKTQGKYSSTVDKVQDAAKNYVDSNRTDKGEQPN

Download         Length: 207 bp

>AT68617 NZ_CP018043:5595408-5595614 [Mycobacterium sp. WY10]
ATGGGATTCCTCGACAAAGCCCTCGGCAAGACCAAGGAAGTTCTCGGCTCCAATGCCGACAAGGTGGAGCAGGCCATCGA
CAAGGCCGGCGACATCATCGATCAGAAGACGCAGGGCAAGTACTCCAGCACCGTCGACAAGGTGCAGGACGCCGCCAAGA
ACTACGTCGACTCCAACCGCACCGACAAAGGCGAGCAACCCAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0UFA4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0UF69

References