Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 3536330..3536907 Replicon chromosome
Accession NZ_CP018043
Organism Mycobacterium sp. WY10

Toxin (Protein)


Gene name doc Uniprot ID A0A1J0UAG7
Locus tag BOH72_RS17465 Protein ID WP_071947609.1
Coordinates 3536330..3536713 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1J0UHJ1
Locus tag BOH72_RS17470 Protein ID WP_071950092.1
Coordinates 3536710..3536907 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOH72_RS17435 3531787..3532269 + 483 WP_071947603.1 hypothetical protein -
BOH72_RS17440 3532280..3533938 - 1659 WP_156909822.1 hypothetical protein -
BOH72_RS17445 3533980..3534378 - 399 WP_071947605.1 type II toxin-antitoxin system VapC family toxin -
BOH72_RS17450 3534375..3534638 - 264 WP_071947606.1 type II toxin-antitoxin system VapB family antitoxin -
BOH72_RS17455 3534702..3535613 - 912 WP_071947607.1 hypothetical protein -
BOH72_RS17460 3535672..3536250 - 579 WP_071947608.1 hypothetical protein -
BOH72_RS17465 3536330..3536713 - 384 WP_071947609.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
BOH72_RS17470 3536710..3536907 - 198 WP_071950092.1 antitoxin Phd Antitoxin
BOH72_RS17475 3537041..3537289 + 249 WP_071947610.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
BOH72_RS17490 3537558..3538717 + 1160 WP_096311543.1 IS3 family transposase -
BOH72_RS17500 3539040..3539465 - 426 WP_071947612.1 hypothetical protein -
BOH72_RS17505 3539530..3540780 - 1251 WP_071947613.1 cytochrome P450 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(19-121)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13535.20 Da        Isoelectric Point: 3.8694

>T68616 WP_071947609.1 NZ_CP018043:c3536713-3536330 [Mycobacterium sp. WY10]
VTEYLDRDDVLVAGAAAVGVELRVADYGLLDAAVARPQATVFGVDAYPDLVTKAAALLQSLARNHALVDGNKRTAWAAAW
TFLYINGVELNPDFDVDDAEDFMNAVAVQGDLELPELAEKLQGFAIG

Download         Length: 384 bp

>T68616 NZ_CP018043:c3536713-3536330 [Mycobacterium sp. WY10]
GTGACCGAATACCTGGACCGTGACGATGTCCTGGTCGCCGGTGCTGCGGCGGTGGGGGTCGAGCTGAGAGTGGCCGACTA
CGGCCTGCTCGATGCGGCGGTGGCGCGCCCGCAGGCTACCGTCTTCGGTGTTGACGCCTATCCTGACCTCGTCACCAAGG
CGGCGGCGCTGCTGCAGTCTTTGGCTCGCAACCACGCACTGGTCGACGGCAACAAGCGCACCGCATGGGCAGCCGCGTGG
ACGTTCCTGTACATCAACGGAGTCGAGTTGAACCCCGATTTCGATGTCGACGACGCTGAGGACTTCATGAATGCTGTTGC
CGTCCAAGGTGATCTGGAACTGCCGGAACTGGCAGAGAAGCTGCAAGGATTCGCAATCGGATGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7206.16 Da        Isoelectric Point: 11.5658

>AT68616 WP_071950092.1 NZ_CP018043:c3536907-3536710 [Mycobacterium sp. WY10]
MPALNINFSDAEMEQLRTAAAAGEQSLRAFVHRAALDAASDRKRRVREGARIVAERSAELNRRLA

Download         Length: 198 bp

>AT68616 NZ_CP018043:c3536907-3536710 [Mycobacterium sp. WY10]
ATGCCGGCCTTGAACATCAACTTCAGTGACGCGGAGATGGAGCAGTTGCGCACCGCGGCGGCGGCGGGCGAGCAGTCGTT
GCGCGCATTCGTCCACCGCGCCGCCCTTGATGCCGCGAGCGATCGCAAGCGTCGCGTGCGGGAGGGTGCGCGGATCGTCG
CCGAGCGCAGCGCAGAGCTCAACCGCCGGCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0UAG7

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0UHJ1

References