Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3533980..3534638 Replicon chromosome
Accession NZ_CP018043
Organism Mycobacterium sp. WY10

Toxin (Protein)


Gene name vapC Uniprot ID A0A1J0UAE8
Locus tag BOH72_RS17445 Protein ID WP_071947605.1
Coordinates 3533980..3534378 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1J0UAC6
Locus tag BOH72_RS17450 Protein ID WP_071947606.1
Coordinates 3534375..3534638 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BOH72_RS17425 3529406..3530632 + 1227 WP_071947601.1 TetR/AcrR family transcriptional regulator -
BOH72_RS17430 3530865..3531671 - 807 WP_083542957.1 glycoside hydrolase family 16 protein -
BOH72_RS17435 3531787..3532269 + 483 WP_071947603.1 hypothetical protein -
BOH72_RS17440 3532280..3533938 - 1659 WP_156909822.1 hypothetical protein -
BOH72_RS17445 3533980..3534378 - 399 WP_071947605.1 type II toxin-antitoxin system VapC family toxin Toxin
BOH72_RS17450 3534375..3534638 - 264 WP_071947606.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BOH72_RS17455 3534702..3535613 - 912 WP_071947607.1 hypothetical protein -
BOH72_RS17460 3535672..3536250 - 579 WP_071947608.1 hypothetical protein -
BOH72_RS17465 3536330..3536713 - 384 WP_071947609.1 type II toxin-antitoxin system death-on-curing family toxin -
BOH72_RS17470 3536710..3536907 - 198 WP_071950092.1 antitoxin Phd -
BOH72_RS17475 3537041..3537289 + 249 WP_071947610.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
BOH72_RS17490 3537558..3538717 + 1160 WP_096311543.1 IS3 family transposase -
BOH72_RS17500 3539040..3539465 - 426 WP_071947612.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-86)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13997.86 Da        Isoelectric Point: 4.7025

>T68615 WP_071947605.1 NZ_CP018043:c3534378-3533980 [Mycobacterium sp. WY10]
VIVDTSAIVAIALNESGRDRLVDALVGAAEPKISATTLVEVAAVLMRRLKPEDLRRVERLIDQLGIVTVSFDAEQAANAT
RAYREFGRGSGHRAGLNLGDCYSYALAAVTGEPLLFVGDDFTHTDTTPAALG

Download         Length: 399 bp

>T68615 NZ_CP018043:c3534378-3533980 [Mycobacterium sp. WY10]
GTGATCGTCGATACGTCGGCGATCGTGGCCATAGCGCTCAACGAGTCGGGACGCGATCGGTTAGTCGACGCTCTGGTGGG
CGCGGCCGAGCCGAAGATCTCCGCGACCACGCTGGTCGAGGTGGCGGCGGTCCTCATGAGGCGACTGAAACCCGAAGATT
TGCGACGTGTGGAGCGCCTCATCGACCAATTAGGCATCGTGACAGTATCTTTCGATGCCGAGCAGGCTGCGAATGCCACA
CGCGCCTACCGTGAGTTCGGACGTGGCAGCGGCCATCGCGCAGGCCTGAATCTCGGTGACTGCTACTCCTACGCCCTTGC
CGCGGTCACCGGTGAACCATTGCTGTTCGTCGGCGACGACTTCACCCATACGGATACCACCCCGGCCGCTCTCGGCTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9590.80 Da        Isoelectric Point: 6.3472

>AT68615 WP_071947606.1 NZ_CP018043:c3534638-3534375 [Mycobacterium sp. WY10]
MSLNIKNPQTVALVRELARRTGLSQTSAVEEAVRAKLAQLISGEGGDARRQKVDDLLAELDRSITAQQRKSIRKDETDLY
DENGLPA

Download         Length: 264 bp

>AT68615 NZ_CP018043:c3534638-3534375 [Mycobacterium sp. WY10]
ATGAGTCTGAACATCAAGAACCCGCAGACGGTTGCGCTGGTCCGGGAGCTCGCGCGGCGTACGGGACTCAGTCAGACGAG
CGCCGTCGAAGAAGCGGTGCGCGCCAAGCTTGCCCAGCTCATCTCCGGTGAGGGTGGGGATGCTCGACGCCAGAAGGTCG
ACGACTTGCTCGCCGAACTGGATCGGTCGATCACCGCGCAGCAGCGCAAGTCCATTCGTAAAGACGAAACCGACTTGTAT
GACGAGAACGGGTTGCCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0UAE8

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0UAC6

References