Detailed information of TA system TA068614

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Rv0298-Rv0299/-
• Location: 196280..196806
• Replicon: chromosome
• Accession: NZ_CP018043
• Organism: Mycobacterium sp. WY10

Toxin (Protein)

• Gene name: Rv0299
• Uniprot ID: -
• Locus tag: BOH72_RS00975
• Protein ID: WP_071942669.1
• Coordinates: 196504..196806 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: Rv0298
• Uniprot ID: A0A1J0U2K7
• Locus tag: BOH72_RS00970
• Protein ID: WP_071942667.1
• Coordinates: 196280..196507 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BOH72_RS00950	191566..191823	+	258	WP_156909710.1	hypothetical protein	-
BOH72_RS29895	191932..192315	+	384	WP_125477475.1	hypothetical protein	-
BOH72_RS00955	192242..192967	+	726	WP_071942662.1	hypothetical protein	-
BOH72_RS00960	193448..194425	+	978	Protein_188	IS1380 family transposase	-
BOH72_RS00965	194586..195821	-	1236	WP_071942665.1	IS256 family transposase	-
BOH72_RS00970	196280..196507	+	228	WP_071942667.1	ribbon-helix-helix protein, CopG family	Antitoxin
BOH72_RS00975	196504..196806	+	303	WP_071942669.1	toxin	Toxin
BOH72_RS00980	196866..197552	+	687	WP_071942671.1	hypothetical protein	-
BOH72_RS29900	197777..198010	-	234	Protein_193	hypothetical protein	-
BOH72_RS00990	198268..201771	-	3504	WP_198044356.1	indolepyruvate ferredoxin oxidoreductase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Ribbon-helix-helix protein, CopG (6-41)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 10398.96 Da
• Isoelectric Point: 4.1775

>T68614 WP_071942669.1 NZ_CP018043:196504-196806 [Mycobacterium sp. WY10]
VIAPGDIAPRRDTSHEVYVVVLSNSIHLAADTGRVITCPFIPGEIPDAAMALVVRVEHPEGVALPELVQWLPVAALDEPI
GNIGTNALGDTASLVTALVT

Nucleotide

• Length: 303 bp

>T68614 NZ_CP018043:196504-196806 [Mycobacterium sp. WY10]
GTGATCGCTCCCGGTGACATCGCGCCACGTCGCGATACCAGCCATGAGGTCTATGTTGTCGTGCTGTCTAACTCGATTCA
CCTGGCAGCCGATACCGGCCGAGTCATTACCTGCCCTTTTATTCCAGGCGAAATCCCCGACGCTGCAATGGCGTTGGTCG
TTCGAGTCGAACACCCCGAAGGCGTGGCGCTACCCGAGCTTGTTCAGTGGCTTCCCGTAGCAGCACTGGACGAGCCGATC
GGCAACATCGGGACGAACGCGCTAGGTGACACAGCGTCTCTCGTAACAGCCCTCGTCACCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8197.28 Da
• Isoelectric Point: 8.5261

>AT68614 WP_071942667.1 NZ_CP018043:196280-196507 [Mycobacterium sp. WY10]
MAKDKVSITLNQDVLAKADADAKAAGLNRSELVEQALRHEHLRIALKSYTSTTVPALSIDDYAQRIYQANRASGL

Nucleotide

• Length: 228 bp

>AT68614 NZ_CP018043:196280-196507 [Mycobacterium sp. WY10]
ATGGCGAAAGACAAGGTGTCGATCACACTCAATCAGGACGTGCTGGCAAAGGCCGATGCCGACGCCAAAGCCGCTGGGCT
CAACCGGTCCGAATTGGTTGAGCAGGCTTTGCGCCACGAGCACCTTCGGATCGCGCTCAAGAGCTACACATCGACGACCG
TCCCCGCGCTGAGCATCGACGATTACGCGCAGAGGATCTACCAGGCGAATCGGGCCTCGGGTCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1J0U2K7