Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1913341..1915028 Replicon chromosome
Accession NZ_CP018034
Organism Glaesserella parasuis str. Nagasaki

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag A2U21_RS09800 Protein ID WP_021110343.1
Coordinates 1913685..1915028 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag A2U21_RS09795 Protein ID WP_015940035.1
Coordinates 1913341..1913685 (-) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U21_RS09775 1909409..1910359 - 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -
A2U21_RS09780 1910387..1911232 - 846 WP_021110346.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
A2U21_RS09785 1911234..1911866 - 633 WP_021110345.1 lipoprotein insertase outer membrane protein LolB -
A2U21_RS09790 1911987..1913312 - 1326 WP_021110344.1 ATP-dependent RNA helicase SrmB -
A2U21_RS09795 1913341..1913685 - 345 WP_015940035.1 helix-turn-helix domain-containing protein Antitoxin
A2U21_RS09800 1913685..1915028 - 1344 WP_021110343.1 type II toxin-antitoxin system HipA family toxin Toxin
A2U21_RS09805 1915142..1915579 - 438 WP_021110342.1 ribosomal protein S18-alanine N-acetyltransferase -
A2U21_RS09810 1915821..1916261 - 441 WP_016528419.1 M23 family metallopeptidase -
A2U21_RS09815 1916263..1916676 - 414 WP_005713136.1 DNA polymerase III subunit psi -
A2U21_RS09820 1916759..1917700 + 942 WP_005713135.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
A2U21_RS09825 1917850..1920027 + 2178 WP_021110341.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51032.99 Da        Isoelectric Point: 5.0229

>T68599 WP_021110343.1 NZ_CP018034:c1915028-1913685 [Glaesserella parasuis str. Nagasaki]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPYRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPTAQQNYLLLKQGTIAPVGHLRVKQAVSSFIENEPPRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSAIDCDILRAEFHYYHELASMGFDTIDTTKMRLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIENSHLVETGMAFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKSHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

>T68599 NZ_CP018034:c1915028-1913685 [Glaesserella parasuis str. Nagasaki]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGCCTCAATGATTTTAGCTATCTCTATGATTTAGCAGAGATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ATCCTGTGGAGTTTTTCCCATACCGTAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTTCCTTCTGGAGCAAGT
CGGCGTTATTGGTTGCAAAAACTTGATATTGCTCATTTGCCGACAGCTCAACAAAACTATTTGTTATTAAAACAAGGTAC
GATTGCACCTGTCGGGCATTTACGAGTGAAGCAAGCGGTCAGTTCTTTTATCGAAAATGAACCCCCTCGCTTATTTGAAA
TAGATGATGTTATCAATCGCCAAGCTGATTTTTTGGAATATGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCAACGGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGACGATTTCTATTTAGTCAAGTTTCCGCGTGGAAAACGCAGTGCAATAGATTGCGACATATTGAGAGCTGAAT
TTCACTATTACCACGAATTAGCCTCAATGGGTTTTGATACCATTGATACGACAAAAATGCGGTTGGAAGAGGGCGAACGT
TACCCGTCGTTATGGTTACCTCGCTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGATATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCCAAAATTGAAA
ATTCTCACCTAGTTGAAACAGGAATGGCTTTTGATAAACAGGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGGCGAAATACCGCTTTCTTACGCAATCAAAATCGTATTTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCGGATCCTGAAGGCATTCCTCGTACGACAATGTGGGATAGTAAAAGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTCCAGCCGACAAGTTATTGGAT
GCTTTGCGTCAAACGGCTCAACAGCTTGTCGGACTTAAAGCACGTTTAGAAGCAAGGGGCGTTCCAACGGCGATTTTGAC
GTATCCTTCAATCAGTTTGGACTATTTACCTGAAAAATTAAAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13225.52 Da        Isoelectric Point: 10.2782

>AT68599 WP_015940035.1 NZ_CP018034:c1913685-1913341 [Glaesserella parasuis str. Nagasaki]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPMNKTLLRQVLNEQAV

Download         Length: 345 bp

>AT68599 NZ_CP018034:c1913685-1913341 [Glaesserella parasuis str. Nagasaki]
ATGGAAGAGATCAAACAGGCGAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGAGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGAAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAACTAGGTGTTGTGCCAATGAACAAAACACTACTCAGACA
AGTTTTAAACGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References