Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-stbD/ParE-DnaT
Location 1606636..1607171 Replicon chromosome
Accession NZ_CP018034
Organism Glaesserella parasuis str. Nagasaki

Toxin (Protein)


Gene name relE Uniprot ID A0A836YZW4
Locus tag A2U21_RS08295 Protein ID WP_016528228.1
Coordinates 1606636..1606920 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A836Z1U9
Locus tag A2U21_RS08300 Protein ID WP_010785924.1
Coordinates 1606917..1607171 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U21_RS08275 1602267..1602758 + 492 WP_016528224.1 acetolactate synthase small subunit -
A2U21_RS08280 1602865..1603686 - 822 WP_021110404.1 PHP domain-containing protein -
A2U21_RS08285 1603835..1604794 - 960 WP_021110405.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
A2U21_RS08290 1604877..1606427 - 1551 WP_021110406.1 exodeoxyribonuclease I -
A2U21_RS08295 1606636..1606920 - 285 WP_016528228.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
A2U21_RS08300 1606917..1607171 - 255 WP_010785924.1 plasmid stability protein StbD Antitoxin
A2U21_RS08305 1607289..1608044 - 756 WP_012621503.1 ABC transporter permease -
A2U21_RS08310 1608066..1608962 - 897 WP_021110407.1 ABC transporter ATP-binding protein -
A2U21_RS08315 1608968..1610986 - 2019 WP_021110408.1 DNA polymerase III subunit gamma/tau -
A2U21_RS08320 1611074..1611616 - 543 WP_005712695.1 adenine phosphoribosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11276.27 Da        Isoelectric Point: 10.5362

>T68597 WP_016528228.1 NZ_CP018034:c1606920-1606636 [Glaesserella parasuis str. Nagasaki]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
RERNDVYQKVQLRL

Download         Length: 285 bp

>T68597 NZ_CP018034:c1606920-1606636 [Glaesserella parasuis str. Nagasaki]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTGTATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9333.70 Da        Isoelectric Point: 4.4131

>AT68597 WP_010785924.1 NZ_CP018034:c1607171-1606917 [Glaesserella parasuis str. Nagasaki]
MPSVILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT68597 NZ_CP018034:c1607171-1606917 [Glaesserella parasuis str. Nagasaki]
ATGCCAAGTGTTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836YZW4

Antitoxin

Source ID Structure
AlphaFold DB A0A836Z1U9

References