Detailed information of TA system TA068592

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 863749..864526
• Replicon: chromosome
• Accession: NZ_CP018034
• Organism: Glaesserella parasuis str. Nagasaki

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: A2U21_RS04470
• Protein ID: WP_021109671.1
• Coordinates: 863749..864249 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: A2U21_RS04475
• Protein ID: WP_005710653.1
• Coordinates: 864239..864526 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
A2U21_RS04435	858874..859029	-	156	WP_021109675.1	YoaH family protein	-
A2U21_RS04440	859047..859775	-	729	WP_021109674.1	tRNA pseudouridine(65) synthase TruC	-
A2U21_RS04445	859772..860086	-	315	WP_005710664.1	YqcC family protein	-
A2U21_RS04450	860128..861042	-	915	WP_021109673.1	N-acetylmuramic acid 6-phosphate etherase	-
A2U21_RS04455	861054..862169	-	1116	WP_021109672.1	anhydro-N-acetylmuramic acid kinase	-
A2U21_RS04460	862324..862659	-	336	WP_005710658.1	outer membrane protein assembly factor BamE	-
A2U21_RS04465	862720..863721	-	1002	WP_005710656.1	nucleoid-associated protein YejK	-
A2U21_RS04470	863749..864249	-	501	WP_021109671.1	GNAT family N-acetyltransferase	Toxin
A2U21_RS04475	864239..864526	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
A2U21_RS04480	864672..865061	+	390	WP_021109670.1	RidA family protein	-
A2U21_RS04485	865065..865802	+	738	WP_021109669.1	peptidoglycan editing factor PgeF	-
A2U21_RS04490	865977..867554	+	1578	WP_021109668.1	FAD-binding protein	-
A2U21_RS04495	867658..868158	+	501	WP_021109667.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19155.30 Da
• Isoelectric Point: 8.9912

>T68592 WP_021109671.1 NZ_CP018034:c864249-863749 [Glaesserella parasuis str. Nagasaki]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYSRQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
DYYPIPLFTLARLAVDIRYQKQGIGGMLLVKALKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMPLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T68592 NZ_CP018034:c864249-863749 [Glaesserella parasuis str. Nagasaki]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACTCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GACTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT68592 WP_005710653.1 NZ_CP018034:c864526-864239 [Glaesserella parasuis str. Nagasaki]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT68592 NZ_CP018034:c864526-864239 [Glaesserella parasuis str. Nagasaki]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTCACCCATACGAATATTACAGAATTTGTATTACAACGCATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: U4SPD7