Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 599638..600177 Replicon chromosome
Accession NZ_CP018034
Organism Glaesserella parasuis str. Nagasaki

Toxin (Protein)


Gene name relE Uniprot ID A0A6I5WQI8
Locus tag A2U21_RS03165 Protein ID WP_005714578.1
Coordinates 599908..600177 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B8F4J9
Locus tag A2U21_RS03160 Protein ID WP_005714576.1
Coordinates 599638..599904 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U21_RS03125 596573..596899 + 327 WP_021109618.1 DUF2190 family protein -
A2U21_RS03130 596892..597197 + 306 WP_005714563.1 phage tail protein -
A2U21_RS03135 597201..597734 + 534 WP_005714565.1 phage tail protein -
A2U21_RS03140 597734..598153 + 420 WP_005714567.1 phage tail protein -
A2U21_RS03145 598156..598821 + 666 WP_010786321.1 hypothetical protein -
A2U21_RS03150 598895..599296 + 402 WP_005714571.1 hypothetical protein -
A2U21_RS03155 599341..599568 + 228 WP_005714573.1 DUF4035 domain-containing protein -
A2U21_RS03160 599638..599904 + 267 WP_005714576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
A2U21_RS03165 599908..600177 + 270 WP_005714578.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
A2U21_RS03170 600323..600891 - 569 Protein_583 transposase -
A2U21_RS03175 600995..601210 + 216 WP_035498906.1 hypothetical protein -
A2U21_RS03180 601413..601688 + 276 WP_005714514.1 hypothetical protein -
A2U21_RS03185 601744..605118 + 3375 WP_021110225.1 phage tail tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 573521..615030 41509
- flank IS/Tn - - 600323..600709 386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-80)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.03 Da        Isoelectric Point: 6.8591

>T68591 WP_005714578.1 NZ_CP018034:599908-600177 [Glaesserella parasuis str. Nagasaki]
MLQLSPTNAYKRDFKKIASELMSSAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Download         Length: 270 bp

>T68591 NZ_CP018034:599908-600177 [Glaesserella parasuis str. Nagasaki]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGTCTAGTGCTGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9945.38 Da        Isoelectric Point: 5.0366

>AT68591 WP_005714576.1 NZ_CP018034:599638-599904 [Glaesserella parasuis str. Nagasaki]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Download         Length: 267 bp

>AT68591 NZ_CP018034:599638-599904 [Glaesserella parasuis str. Nagasaki]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAAACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAAAATGAAGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5WQI8

Antitoxin

Source ID Structure
AlphaFold DB B8F4J9

References