Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2220884..2222433 Replicon chromosome
Accession NZ_CP018032
Organism Glaesserella parasuis D74

Toxin (Protein)


Gene name hipA Uniprot ID A0A384XTX5
Locus tag A2U20_RS10745 Protein ID WP_043895959.1
Coordinates 2220884..2222200 (-) Length 439 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID U4SAZ6
Locus tag A2U20_RS10750 Protein ID WP_010786623.1
Coordinates 2222194..2222433 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A2U20_RS10725 2216394..2217266 + 873 WP_021117728.1 LysR family transcriptional regulator -
A2U20_RS10730 2217327..2217941 - 615 WP_021111869.1 DsbA family protein -
A2U20_RS10735 2218064..2218954 + 891 WP_021117727.1 LysR family transcriptional regulator -
A2U20_RS12185 2219500..2219736 + 237 WP_200859965.1 GntR family transcriptional regulator -
A2U20_RS10740 2219744..2220880 + 1137 WP_202117110.1 PLP-dependent aminotransferase family protein -
A2U20_RS10745 2220884..2222200 - 1317 WP_043895959.1 type II toxin-antitoxin system HipA family toxin Toxin
A2U20_RS10750 2222194..2222433 - 240 WP_010786623.1 helix-turn-helix domain-containing protein Antitoxin
A2U20_RS10755 2222581..2223408 - 828 WP_005713289.1 alpha/beta hydrolase -
A2U20_RS10760 2223539..2224984 + 1446 WP_021116416.1 metalloprotease TldD -
A2U20_RS10765 2225238..2225648 + 411 WP_020457617.1 preprotein translocase subunit SecE -
A2U20_RS10770 2225650..2226228 + 579 WP_020457616.1 transcription termination/antitermination protein NusG -
A2U20_RS10775 2226340..2226950 + 611 Protein_2083 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2226648..2226956 308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-104)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-66)


Sequences

Toxin        


Download         Length: 439 a.a.        Molecular weight: 49964.28 Da        Isoelectric Point: 8.2623

>T68589 WP_043895959.1 NZ_CP018032:c2222200-2220884 [Glaesserella parasuis D74]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATALNESEMAKILQSYQYNVPLGMIDNNQDFRISIAGAQEKT
ALLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGIGIGDMMNKLLYSSNSNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDRVATTLPKQIDENVRDQIFTGVIKQVQKVSMK

Download         Length: 1317 bp

>T68589 NZ_CP018032:c2222200-2220884 [Glaesserella parasuis D74]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCTTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGCATTAAACGAGAGTGAAATGGCGAAAATTCTACAAAGTT
ATCAATACAATGTCCCACTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAGACA
GCTCTGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCGGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAATTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATTCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACACGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGCACGCAAAAAGGAAAAAAATGGCATTGGAGTAAAATTTATGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGTTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGAGTAGCAACAACATTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CGTAATAAAACAGGTACAAAAAGTTTCTATGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9059.47 Da        Isoelectric Point: 9.7684

>AT68589 WP_010786623.1 NZ_CP018032:c2222433-2222194 [Glaesserella parasuis D74]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Download         Length: 240 bp

>AT68589 NZ_CP018032:c2222433-2222194 [Glaesserella parasuis D74]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TCAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAACGATGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A384XTX5

Antitoxin

Source ID Structure
AlphaFold DB U4SAZ6

References