Detailed information of TA system TA068580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 2563143..2563788
• Replicon: chromosome
• Accession: NZ_CP018031
• Organism: Alteromonas sp. RW2A1

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: BM528_RS11425
• Protein ID: WP_083595269.1
• Coordinates: 2563143..2563403 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A2K8XZ52
• Locus tag: BM528_RS11430
• Protein ID: WP_071979919.1
• Coordinates: 2563384..2563788 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BM528_RS11415	2560983..2562230	-	1248	WP_071979917.1	efflux RND transporter periplasmic adaptor subunit	-
BM528_RS11420	2562491..2563165	+	675	WP_071979918.1	hypothetical protein	-
BM528_RS11425	2563143..2563403	-	261	WP_083595269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BM528_RS11430	2563384..2563788	-	405	WP_071979919.1	S-adenosylhomocysteine hydrolase	Antitoxin
BM528_RS18390	2563946..2564086	-	141	WP_083595270.1	tyrosine-type recombinase/integrase	-
BM528_RS11440	2564238..2565581	-	1344	WP_071979920.1	restriction endonuclease subunit S	-
BM528_RS11445	2565581..2567191	-	1611	WP_071979921.1	N-6 DNA methylase	-
BM528_RS11450	2567220..2568299	-	1080	WP_071979922.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-76)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 9616.05 Da
• Isoelectric Point: 6.2105

>T68580 WP_083595269.1 NZ_CP018031:c2563403-2563143 [Alteromonas sp. RW2A1]
VSTKLDSSLFVDVADAIGLGNPAIVEKDYYVVQLLRHLSIIEFEHHQLVFTGGTALAKSDIKTYRMSEDIDIKLVPNKVF
NNLPSR

Nucleotide

• Length: 261 bp

>T68580 NZ_CP018031:c2563403-2563143 [Alteromonas sp. RW2A1]
GTGTCAACGAAGCTCGATAGCTCGCTATTTGTCGATGTTGCCGACGCCATAGGGCTAGGCAACCCGGCAATTGTCGAAAA
GGACTACTATGTTGTCCAATTATTAAGGCATCTATCGATAATCGAATTCGAACACCACCAGTTGGTATTCACGGGCGGCA
CTGCACTTGCCAAGTCTGATATAAAAACGTATCGCATGTCGGAAGATATCGATATTAAGCTGGTTCCCAACAAGGTATTT
AATAATCTACCATCACGATAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15194.52 Da
• Isoelectric Point: 10.8456

>AT68580 WP_071979919.1 NZ_CP018031:c2563788-2563384 [Alteromonas sp. RW2A1]
MTIQDRIKTRVKRSKRSVFLRSDFKDIADYDQVGRGLRNLAREGLLMKIGYGLYARARVNRITGKLMPDNAAGADGVLIE
AMERLDVDYKFDDLSNMNFSGQSTQIPASVKIVPTDPRFTRKITVGKQRVNEAR

Nucleotide

• Length: 405 bp

>AT68580 NZ_CP018031:c2563788-2563384 [Alteromonas sp. RW2A1]
ATGACGATACAAGACAGAATAAAGACAAGAGTCAAGCGTTCTAAGCGTTCTGTTTTTTTGCGCTCTGATTTTAAAGATAT
AGCTGACTACGACCAAGTAGGTCGAGGCCTTAGAAATCTTGCTCGTGAAGGCTTGTTGATGAAGATAGGTTACGGGCTTT
ATGCCCGTGCCAGAGTCAATCGCATTACAGGTAAATTAATGCCGGATAATGCTGCGGGTGCTGATGGTGTACTAATAGAA
GCTATGGAAAGATTAGATGTAGACTACAAGTTCGATGATTTGTCGAACATGAACTTTTCAGGCCAGAGTACGCAAATTCC
AGCTAGTGTTAAAATTGTTCCAACCGATCCACGCTTTACCCGTAAAATTACCGTAGGTAAGCAGCGTGTCAACGAAGCTC
GATAG

Structures

Antitoxin

• AlphaFold DB: A0A2K8XZ52