Detailed information of TA system TA068577

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): sdenTA/AbiEii(toxin)
• Location: 94244..95675
• Replicon: chromosome
• Accession: NZ_CP018031
• Organism: Alteromonas sp. RW2A1

Toxin (Protein)

• Gene name: sdenT
• Uniprot ID: -
• Locus tag: BM528_RS00475
• Protein ID: WP_071978203.1
• Coordinates: 94776..95675 (+)
• Length: 300 a.a.

Antitoxin (Protein)

• Gene name: sdenA
• Uniprot ID: A0A2K8XV75
• Locus tag: BM528_RS00470
• Protein ID: WP_071978202.1
• Coordinates: 94244..94783 (+)
• Length: 180 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BM528_RS00445	89878..90432	-	555	WP_198033580.1	DsrE family protein	-
BM528_RS00450	90449..90868	-	420	WP_071978198.1	YeeE/YedE family protein	-
BM528_RS00455	90889..91317	-	429	WP_083595134.1	YeeE/YedE family protein	-
BM528_RS00460	92030..93346	+	1317	WP_071978200.1	bifunctional diguanylate cyclase/phosphodiesterase	-
BM528_RS00465	93352..93789	+	438	WP_071978201.1	BLUF domain-containing protein	-
BM528_RS18415	93859..94113	-	255	WP_198033581.1	hypothetical protein	-
BM528_RS00470	94244..94783	+	540	WP_071978202.1	hypothetical protein	Antitoxin
BM528_RS00475	94776..95675	+	900	WP_071978203.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
BM528_RS00480	95696..96517	-	822	WP_071978204.1	MipA/OmpV family protein	-
BM528_RS00485	97064..97456	+	393	WP_071978205.1	OsmC family protein	-
BM528_RS00490	97527..98840	-	1314	WP_071978206.1	type II toxin-antitoxin system HipA family toxin	-
BM528_RS00495	98840..99106	-	267	WP_071978207.1	helix-turn-helix domain-containing protein	-
BM528_RS00500	99403..100011	+	609	Protein_90	hypothetical protein	-
BM528_RS18600	100313..100468	-	156	WP_198033582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-254)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 300 a.a.
• Molecular weight: 34153.22 Da
• Isoelectric Point: 7.9852

>T68577 WP_071978203.1 NZ_CP018031:94776-95675 [Alteromonas sp. RW2A1]
MISDLVSQAIEKNPQLIGLEDVVEKEIVHHELLNILHKEGFLGHLTFIGGTALRMCYGSNRLSEDLDFTGGAHFSPKDFS
SLSADIESHLQNKFMLDVNVREPLIDRSDTSTWKVTIIKNPKRPDLPSQKMHIDICRYDSFDKVQRPAKNFYDINSPIEG
LPIPVQSSKEILADKLIALAFRERRIKPRDVWDLAWLSQQNVPIEASLVKKKLVMRGKTQKGFLKNLQIHSGSILTSDET
KLDFEREMLRFVPKDIRERTLNRKEFWPYVGETIASQIETIGSALNRNSTNGHGSDMKM

Nucleotide

• Length: 900 bp

>T68577 NZ_CP018031:94776-95675 [Alteromonas sp. RW2A1]
ATGATTAGTGATTTGGTCTCTCAGGCGATTGAGAAGAACCCTCAATTAATAGGGTTGGAAGATGTAGTAGAAAAAGAGAT
TGTGCATCATGAGTTGCTTAACATTCTGCATAAAGAAGGGTTTCTGGGACATCTCACTTTTATCGGCGGAACGGCTTTAC
GTATGTGCTATGGCTCTAATCGCTTGTCAGAAGACTTGGACTTCACAGGAGGGGCGCATTTTTCACCTAAAGACTTCTCT
TCGTTATCTGCCGATATCGAGTCGCACTTGCAAAACAAATTCATGCTAGACGTTAATGTGCGCGAGCCTTTAATAGACCG
CAGTGACACATCAACCTGGAAAGTGACTATTATCAAAAACCCTAAGCGGCCAGACTTACCTTCACAGAAGATGCACATCG
ATATTTGCCGCTATGATTCATTTGATAAGGTTCAGCGCCCTGCTAAAAATTTTTATGATATAAATTCGCCTATTGAAGGC
TTACCAATTCCGGTACAAAGCAGCAAAGAGATACTGGCCGACAAGCTGATTGCGTTAGCGTTTCGAGAGCGCCGGATAAA
ACCACGGGACGTGTGGGACTTAGCATGGCTAAGCCAACAGAACGTTCCGATTGAAGCTTCACTGGTAAAAAAGAAGCTTG
TAATGCGTGGTAAAACTCAGAAAGGTTTTCTCAAAAATCTACAGATACACAGTGGATCCATTCTGACGTCGGATGAGACG
AAATTAGACTTTGAAAGAGAAATGTTACGATTTGTCCCTAAAGATATCCGTGAACGTACCTTAAATCGCAAGGAGTTTTG
GCCATATGTGGGTGAAACGATAGCCTCACAAATCGAGACAATTGGATCGGCGCTGAATAGAAATTCCACAAATGGCCACG
GTTCGGACATGAAGATGTAG

Antitoxin

Protein

• Length: 180 a.a.
• Molecular weight: 20534.47 Da
• Isoelectric Point: 10.1355

>AT68577 WP_071978202.1 NZ_CP018031:94244-94783 [Alteromonas sp. RW2A1]
MSFALKVTSTLHKAIKNGHFGIFTTHDIALSLLESADDNFRKKLSKGVSRGWLLKVCRDMYALPSDEPTKRGVLEYIASR
LHWNKFIYVSLESELSRQGVISQIPFSYLTVMTQGRSGKIETRYGTIEFTHTNRKNRTAEDVYYDPDTRIFRARAKRAIA
DLKRVGRNVDMINEEAVND

Nucleotide

• Length: 540 bp

>AT68577 NZ_CP018031:94244-94783 [Alteromonas sp. RW2A1]
ATGAGTTTTGCTCTTAAGGTTACTAGTACACTACACAAAGCCATAAAAAACGGGCACTTCGGTATATTTACGACTCACGA
TATTGCATTATCTTTATTAGAAAGCGCTGATGATAATTTTCGAAAAAAACTTTCTAAAGGTGTTTCAAGAGGGTGGCTAT
TGAAAGTATGCCGAGACATGTATGCATTGCCCAGTGATGAGCCTACAAAGCGAGGCGTGCTTGAATATATTGCATCGCGC
CTGCATTGGAATAAATTCATATACGTCAGTCTCGAAAGTGAGCTCTCAAGGCAAGGAGTAATATCGCAAATTCCTTTTAG
TTACCTTACCGTTATGACACAAGGTCGAAGTGGGAAAATAGAGACGCGATATGGAACCATTGAGTTTACGCATACCAATC
GAAAAAACCGAACGGCAGAAGATGTGTATTATGATCCAGATACACGAATTTTCCGGGCCAGAGCCAAGCGCGCAATAGCT
GATTTAAAGCGGGTCGGGAGAAATGTGGATATGATAAATGAAGAGGCAGTGAATGATTAG

Structures

Antitoxin

• AlphaFold DB: A0A2K8XV75