Detailed information of TA system TA068558

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 1095528..1096092
• Replicon: chromosome
• Accession: NZ_CP018020
• Organism: Mycobacterium avium subsp. hominissuis strain OCU873s_P7_4s

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A2A2ZLT9
• Locus tag: BJP74_RS05490
• Protein ID: WP_023868517.1
• Coordinates: 1095721..1096092 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: BJP74_RS05485
• Protein ID: WP_011724021.1
• Coordinates: 1095528..1095734 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP74_RS05465	1090785..1091783	+	999	WP_023868514.1	4-hydroxy-3-methylbut-2-enyl diphosphate reductase	-
BJP74_RS05470	1091807..1093012	-	1206	WP_179148812.1	hypothetical protein	-
BJP74_RS05475	1093143..1094216	+	1074	WP_023868516.1	redox-regulated ATPase YchF	-
BJP74_RS05480	1094416..1095360	+	945	WP_003875389.1	HNH endonuclease	-
BJP74_RS05485	1095528..1095734	+	207	WP_011724021.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
BJP74_RS05490	1095721..1096092	+	372	WP_023868517.1	type II toxin-antitoxin system VapC family toxin	Toxin
BJP74_RS05495	1096192..1096632	+	441	WP_003875392.1	nitroreductase family deazaflavin-dependent oxidoreductase	-
BJP74_RS05500	1096698..1097435	-	738	WP_023868518.1	glucose 1-dehydrogenase	-
BJP74_RS05505	1097510..1098115	+	606	WP_095956146.1	TetR/AcrR family transcriptional regulator; helix-turn-helix transcriptional regulator	-
BJP74_RS05510	1098217..1098615	+	399	WP_071321381.1	VOC family protein	-
BJP74_RS05515	1098684..1099067	+	384	WP_011724026.1	hypothetical protein	-
BJP74_RS05520	1099137..1099490	+	354	WP_023865350.1	hypothetical protein	-
BJP74_RS23800	1099647..1100012	+	366	Protein_1074	hypothetical protein	-
BJP74_RS05530	1100642..1100965	+	324	WP_044543559.1	antibiotic biosynthesis monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-112)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13754.08 Da
• Isoelectric Point: 6.6032

>T68558 WP_023868517.1 NZ_CP018020:1095721-1096092 [Mycobacterium avium subsp. hominissuis]
MILVDTSVWIDHLHVADKRLIEFLTNDAIGCHQMVIEELALGAIRRRADLLRLLSNLRAFPLLTHAEVLHLVESHRLWGR
GLSAIDVHLLGSVALVDGARLWTRDKNLKAAGWDVGIAIVDEL

Nucleotide

• Length: 372 bp

>T68558 NZ_CP018020:1095721-1096092 [Mycobacterium avium subsp. hominissuis]
ATGATTCTCGTTGACACGTCGGTATGGATCGATCATCTGCACGTCGCCGACAAGCGACTCATAGAGTTCCTGACCAACGA
CGCAATCGGTTGCCACCAAATGGTGATCGAGGAGTTGGCATTGGGTGCGATCAGGCGGCGCGCCGATCTATTGCGCCTGC
TGTCCAATCTTCGGGCGTTCCCGTTGCTGACGCATGCGGAGGTCCTTCATCTCGTCGAAAGCCACCGCTTGTGGGGCCGC
GGACTGAGTGCGATCGACGTCCATCTTCTTGGGTCGGTTGCTCTGGTCGACGGTGCACGGCTATGGACCAGGGACAAGAA
TTTAAAAGCGGCGGGCTGGGACGTGGGTATCGCGATCGTCGACGAGCTCTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7261.25 Da
• Isoelectric Point: 11.0634

>AT68558 WP_011724021.1 NZ_CP018020:1095528-1095734 [Mycobacterium avium subsp. hominissuis]
MRTTVTIDDALLAEAAELTGVTESVALLRQGLQTLVRVESARRLAALGGTDRKASVGPRRRTPADDSR

Nucleotide

• Length: 207 bp

>AT68558 NZ_CP018020:1095528-1095734 [Mycobacterium avium subsp. hominissuis]
ATGAGGACGACGGTGACGATTGACGACGCCTTATTGGCAGAGGCGGCCGAACTGACCGGGGTGACAGAGAGCGTGGCGCT
CCTCCGTCAGGGACTGCAGACACTCGTTCGGGTAGAGAGCGCCCGTCGGCTGGCGGCGCTCGGCGGCACGGATCGGAAGG
CATCGGTCGGCCCTCGCCGGAGGACACCCGCCGATGATTCTCGTTGA

Structures

Toxin

• AlphaFold DB: A0A2A2ZLT9