Detailed information of TA system TA068557

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 872135..872788
• Replicon: chromosome
• Accession: NZ_CP018020
• Organism: Mycobacterium avium subsp. hominissuis strain OCU873s_P7_4s

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: BJP74_RS04420
• Protein ID: WP_003872880.1
• Coordinates: 872327..872788 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: A0A808C2V3
• Locus tag: BJP74_RS04415
• Protein ID: WP_023869662.1
• Coordinates: 872135..872323 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP74_RS04405	868117..869703	+	1587	WP_023869664.1	serine hydrolase	-
BJP74_RS04410	869700..872072	+	2373	WP_137447064.1	cation-translocating P-type ATPase	-
BJP74_RS04415	872135..872323	+	189	WP_023869662.1	antitoxin	Antitoxin
BJP74_RS04420	872327..872788	+	462	WP_003872880.1	SRPBCC family protein	Toxin
BJP74_RS04425	872857..873291	+	435	WP_023869661.1	hypothetical protein	-
BJP74_RS04430	873296..873772	-	477	WP_023869660.1	VOC family protein	-
BJP74_RS04435	874737..876320	+	1584	WP_003872878.1	DUF4185 domain-containing protein	-
BJP74_RS04440	876367..876753	+	387	WP_023869659.1	hypothetical protein	-
BJP74_RS04445	876788..877006	-	219	WP_023869658.1	hypothetical protein	-
BJP74_RS04450	877197..877771	-	575	Protein_868	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16626.19 Da
• Isoelectric Point: 9.5654

>T68557 WP_003872880.1 NZ_CP018020:872327-872788 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T68557 NZ_CP018020:872327-872788 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTATCCGGATCCATCGATGTTCCGCTGCCGCCCGAGGTGGCCTGGCAGCATGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6729.36 Da
• Isoelectric Point: 4.4702

>AT68557 WP_023869662.1 NZ_CP018020:872135-872323 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKVEIAIDKAGEFVDDKTQGKYSDTIHQVQEQAKKATGSTETGDQQG

Nucleotide

• Length: 189 bp

>AT68557 NZ_CP018020:872135-872323 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATTGCCATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCA
GCACCGAGACCGGCGACCAGCAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A808C2V3