Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4903917..4904562 Replicon chromosome
Accession NZ_CP018016
Organism Kosakonia radicincitans DSM 16656

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag Y71_RS23565 Protein ID WP_035886605.1
Coordinates 4903917..4904099 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag Y71_RS23570 Protein ID WP_035943124.1
Coordinates 4904125..4904562 (+) Length 146 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y71_RS23540 4898991..4899944 - 954 WP_007372980.1 helix-turn-helix transcriptional regulator -
Y71_RS23545 4900072..4900977 - 906 WP_007372979.1 LysR family transcriptional regulator -
Y71_RS23550 4901064..4901849 + 786 WP_007372978.1 NAD(P)H-dependent oxidoreductase -
Y71_RS23555 4902041..4902613 + 573 WP_007372977.1 TetR/AcrR family transcriptional regulator -
Y71_RS23560 4902680..4903846 + 1167 WP_007372976.1 multidrug effflux MFS transporter -
Y71_RS23565 4903917..4904099 + 183 WP_035886605.1 type II toxin-antitoxin system HicA family toxin Toxin
Y71_RS23570 4904125..4904562 + 438 WP_035943124.1 hypothetical protein Antitoxin
Y71_RS23575 4904559..4905452 - 894 WP_007372974.1 MurR/RpiR family transcriptional regulator -
Y71_RS23580 4905465..4906412 - 948 WP_007372973.1 ABC transporter substrate-binding protein -
Y71_RS23585 4906427..4907479 - 1053 WP_007372972.1 iron ABC transporter permease -
Y71_RS23590 4907476..4908498 - 1023 WP_035943121.1 iron ABC transporter permease -
Y71_RS23595 4908495..4909319 - 825 WP_007372970.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-82)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6770.97 Da        Isoelectric Point: 11.0174

>T68546 WP_035886605.1 NZ_CP018016:4903917-4904099 [Kosakonia radicincitans DSM 16656]
MKYSEFRKWLLSQGAELTKAPGGGSHFKVRLNGRASVFPFHGSKEIPEPLRKKIMKDLGL

Download         Length: 183 bp

>T68546 NZ_CP018016:4903917-4904099 [Kosakonia radicincitans DSM 16656]
ATGAAATACAGCGAGTTCAGAAAGTGGTTGTTATCTCAGGGAGCGGAGCTAACCAAAGCTCCAGGTGGAGGAAGCCATTT
TAAAGTCAGGCTTAATGGTAGGGCATCGGTTTTCCCTTTTCATGGTTCGAAAGAGATTCCTGAGCCGTTGAGGAAAAAGA
TTATGAAGGACTTAGGCCTGTAA

Antitoxin


Download         Length: 146 a.a.        Molecular weight: 15953.41 Da        Isoelectric Point: 5.5739

>AT68546 WP_035943124.1 NZ_CP018016:4904125-4904562 [Kosakonia radicincitans DSM 16656]
MFNYPVHIERDDATGQFVVSCRDLPLMNSVGDTLDEALLQSIDGIVVAIAIEIDERRPIPAASAPLKGEYIVSLPVLVAM
KAALHNAMIETGTRKAELARKLGQKGPQIDRLLDVEHSSKVETVELALHQLNRQIDLTITPQHRA

Download         Length: 438 bp

>AT68546 NZ_CP018016:4904125-4904562 [Kosakonia radicincitans DSM 16656]
ATGTTTAATTATCCCGTCCACATTGAACGAGACGATGCTACAGGTCAGTTCGTGGTCTCATGCCGCGATCTACCGCTCAT
GAACTCCGTTGGCGATACGCTTGATGAGGCTTTACTGCAGTCGATTGATGGGATTGTTGTTGCGATTGCTATCGAAATTG
ACGAGCGGCGTCCAATCCCGGCGGCAAGCGCGCCGCTAAAAGGCGAATACATCGTATCGCTGCCCGTACTCGTAGCCATG
AAAGCCGCACTGCATAACGCCATGATCGAAACCGGGACGCGAAAAGCTGAGCTGGCAAGAAAGCTGGGACAGAAAGGGCC
GCAAATTGACCGCTTGCTCGATGTGGAGCACTCATCGAAGGTGGAAACGGTTGAACTGGCGCTACATCAGTTAAATCGAC
AGATTGATCTGACCATTACGCCGCAGCACAGAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References