Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4285365..4285981 Replicon chromosome
Accession NZ_CP018016
Organism Kosakonia radicincitans DSM 16656

Toxin (Protein)


Gene name Hha Uniprot ID A0A1C4FBY4
Locus tag Y71_RS20615 Protein ID WP_007373583.1
Coordinates 4285763..4285981 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6M5CWA9
Locus tag Y71_RS20610 Protein ID WP_007373584.1
Coordinates 4285365..4285739 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y71_RS20600 4280486..4281679 + 1194 WP_007373586.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
Y71_RS20605 4281702..4284851 + 3150 WP_007373585.1 multidrug efflux RND transporter permease subunit -
Y71_RS20610 4285365..4285739 + 375 WP_007373584.1 Hha toxicity modulator TomB Antitoxin
Y71_RS20615 4285763..4285981 + 219 WP_007373583.1 hemolysin expression modulator Hha Toxin
Y71_RS20620 4286047..4286607 + 561 WP_007373582.1 maltose O-acetyltransferase -
Y71_RS20625 4286708..4287187 + 480 WP_007373581.1 YlaC family protein -
Y71_RS20630 4287153..4288598 - 1446 WP_007373580.1 PLP-dependent aminotransferase family protein -
Y71_RS20635 4288696..4289398 + 703 Protein_4019 GNAT family N-acetyltransferase -
Y71_RS20640 4289395..4289535 - 141 WP_007373577.1 type B 50S ribosomal protein L36 -
Y71_RS20645 4289539..4289799 - 261 WP_007373576.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8637.05 Da        Isoelectric Point: 7.9893

>T68544 WP_007373583.1 NZ_CP018016:4285763-4285981 [Kosakonia radicincitans DSM 16656]
MSEKPLTKVDYLMRLRRCQTIDTLERVIEKNKYELPDEELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T68544 NZ_CP018016:4285763-4285981 [Kosakonia radicincitans DSM 16656]
ATGTCCGAAAAACCATTAACAAAAGTTGATTATTTGATGCGTCTCAGACGTTGTCAGACAATTGATACCCTTGAACGTGT
AATTGAAAAAAATAAATACGAACTTCCGGATGAGGAACTCGCGGTGTTTTATTCAGCAGCCGATCATCGCCTGGCAGAAC
TGACCATGAATAAGCTGTATGACAAAATCCCCTCCTCCGTGTGGAAATTTGTACGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14567.42 Da        Isoelectric Point: 5.8339

>AT68544 WP_007373584.1 NZ_CP018016:4285365-4285739 [Kosakonia radicincitans DSM 16656]
MDEYSPKRHDIAQLKFLCETLYHDCLVNLEESHHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTHDLQKWRKTGNKLFRCFVNVSKANPVSHSC

Download         Length: 375 bp

>AT68544 NZ_CP018016:4285365-4285739 [Kosakonia radicincitans DSM 16656]
ATGGACGAATACTCGCCAAAAAGGCATGATATCGCGCAGCTCAAATTTCTCTGCGAAACACTGTACCATGACTGCCTTGT
TAATCTCGAAGAGAGCCATCATGGGTGGGTTAACGATCCTACATCAGCGGTGAACTTGCAGTTAAATGAGCTGATAGAAC
ACATAGCGACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAACTGATTGAACAGATAGACGAATATCTT
GACGATACGTTTATGTTGTTCAGTAGCTATGGCATAAATACACATGACTTACAGAAATGGCGCAAAACAGGTAACAAGCT
GTTCCGCTGCTTCGTCAATGTAAGCAAGGCTAATCCTGTTAGCCACTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C4FBY4

Antitoxin

Source ID Structure
AlphaFold DB A0A6M5CWA9

References