Detailed information of TA system TA068543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RHH
• Location: 4081864..4082421
• Replicon: chromosome
• Accession: NZ_CP018016
• Organism: Kosakonia radicincitans DSM 16656

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A6M5D0S3
• Locus tag: Y71_RS19735
• Protein ID: WP_007373777.1
• Coordinates: 4082146..4082421 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: Y71_RS19730
• Protein ID: WP_007373778.1
• Coordinates: 4081864..4082142 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Y71_RS19715	4077831..4078826	-	996	WP_007373782.1	ABC transporter permease	-
Y71_RS19720	4078823..4080325	-	1503	WP_007373781.1	sugar ABC transporter ATP-binding protein	-
Y71_RS19725	4080488..4081576	+	1089	WP_007373780.1	oxidoreductase	-
Y71_RS19730	4081864..4082142	+	279	WP_007373778.1	CopG family ribbon-helix-helix protein	Antitoxin
Y71_RS19735	4082146..4082421	+	276	WP_007373777.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
Y71_RS19740	4082496..4083083	-	588	WP_007373776.1	TetR/AcrR family transcriptional regulator	-
Y71_RS19745	4083195..4083938	+	744	WP_007373775.1	SDR family oxidoreductase	-
Y71_RS19750	4083958..4084155	-	198	WP_000460621.1	YbdD/YjiX family protein	-
Y71_RS19755	4084204..4086309	-	2106	WP_007373774.1	carbon starvation protein CstA	-
Y71_RS19760	4086477..4086890	-	414	WP_007373773.1	proofreading thioesterase EntH	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (7-44)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10835.61 Da
• Isoelectric Point: 5.1100

>T68543 WP_007373777.1 NZ_CP018016:4082146-4082421 [Kosakonia radicincitans DSM 16656]
MQLEWTRLALQDVERLSKFLFIQNPEAARKVVIMLADAPEMLLLHPQIGPPDESWYPREVRSLFVGSYEMIYELTDSHII
ILRIWHTKEDR

Nucleotide

• Length: 276 bp

>T68543 NZ_CP018016:4082146-4082421 [Kosakonia radicincitans DSM 16656]
ATGCAGTTAGAATGGACGCGACTCGCTCTTCAGGATGTAGAGAGACTGTCAAAATTCCTGTTTATCCAAAACCCTGAAGC
CGCCCGCAAAGTTGTCATCATGTTGGCTGACGCCCCTGAAATGCTCTTGCTCCACCCACAAATAGGCCCGCCGGATGAAA
GCTGGTATCCGCGCGAAGTCCGTTCTTTGTTTGTTGGCAGTTATGAAATGATTTACGAACTGACGGACAGCCATATCATC
ATCCTGCGAATCTGGCATACAAAAGAAGACCGTTAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10088.69 Da
• Isoelectric Point: 8.6586

>AT68543 WP_007373778.1 NZ_CP018016:4081864-4082142 [Kosakonia radicincitans DSM 16656]
MPGTKVLTAHVPIELADKVDLLAESSERSRGWIIKRALAEYIERAELRQAMIQQGLDAVERGETVSHAEAATWLKSLGTV
NPMPLPGVKKRG

Nucleotide

• Length: 279 bp

>AT68543 NZ_CP018016:4081864-4082142 [Kosakonia radicincitans DSM 16656]
ATGCCTGGGACGAAAGTACTGACAGCGCATGTACCTATTGAACTCGCCGATAAAGTCGATTTACTTGCCGAAAGCAGCGA
ACGCTCGCGGGGCTGGATTATCAAGCGTGCGCTCGCGGAATATATTGAGCGTGCAGAATTACGCCAGGCCATGATCCAGC
AAGGCCTGGATGCCGTTGAACGCGGTGAAACTGTCAGTCATGCAGAAGCGGCAACCTGGCTTAAAAGTCTGGGGACGGTT
AATCCAATGCCGCTGCCAGGCGTTAAAAAACGGGGATGA

Structures

Toxin

• AlphaFold DB: A0A6M5D0S3