Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 3474126..3474769 Replicon chromosome
Accession NZ_CP018016
Organism Kosakonia radicincitans DSM 16656

Toxin (Protein)


Gene name vagD Uniprot ID A0A3A3ZBE4
Locus tag Y71_RS16790 Protein ID WP_007374381.1
Coordinates 3474126..3474542 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID G8LQB1
Locus tag Y71_RS16795 Protein ID WP_007853351.1
Coordinates 3474539..3474769 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Y71_RS16765 3469610..3469948 - 339 WP_007374386.1 carboxymuconolactone decarboxylase family protein -
Y71_RS16770 3469965..3470534 - 570 WP_035943306.1 TetR/AcrR family transcriptional regulator -
Y71_RS16775 3470718..3471275 - 558 WP_007374384.1 OsmC family protein -
Y71_RS16780 3471484..3472506 - 1023 WP_007374383.1 hypothetical protein -
Y71_RS16785 3472491..3474053 - 1563 WP_007374382.1 AAA family ATPase -
Y71_RS16790 3474126..3474542 - 417 WP_007374381.1 type II toxin-antitoxin system VapC family toxin Toxin
Y71_RS16795 3474539..3474769 - 231 WP_007853351.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
Y71_RS16800 3475032..3477653 - 2622 WP_007374378.1 hypothetical protein -
Y71_RS16805 3478050..3479060 + 1011 WP_007374377.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15105.57 Da        Isoelectric Point: 7.8882

>T68539 WP_007374381.1 NZ_CP018016:c3474542-3474126 [Kosakonia radicincitans DSM 16656]
VNKIYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYAEMRFGATGPKAAPRHVQLVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T68539 NZ_CP018016:c3474542-3474126 [Kosakonia radicincitans DSM 16656]
GTGAACAAAATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGGGGTCACCGCATTGTGGTTTCGGCCATTACCTACGCCGAGATGCGCTTCGGCGCCACCGGGC
CGAAGGCCGCGCCGCGTCACGTCCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATTGGCCCGAACGACACGGCGATTGC
CGGACACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8674.77 Da        Isoelectric Point: 4.4692

>AT68539 WP_007853351.1 NZ_CP018016:c3474769-3474539 [Kosakonia radicincitans DSM 16656]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPDFMAEREDVVSDEGRVNL

Download         Length: 231 bp

>AT68539 NZ_CP018016:c3474769-3474539 [Kosakonia radicincitans DSM 16656]
ATGCGCACAGTCTCTATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A3ZBE4

Antitoxin

Source ID Structure
AlphaFold DB A0A3A3Z894

References