Detailed information of TA system TA068527

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES-TIGR02293
• Location: 3035687..3036585
• Replicon: chromosome
• Accession: NZ_CP018014
• Organism: Mycobacterium avium subsp. hominissuis strain OCU901s_S2_2s

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: -
• Locus tag: BJP78_RS14075
• Protein ID: WP_084024225.1
• Coordinates: 3036025..3036585 (+)
• Length: 187 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: -
• Locus tag: BJP78_RS14070
• Protein ID: WP_084024227.1
• Coordinates: 3035687..3036028 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP78_RS14045	3031969..3032226	-	258	Protein_2724	acyl-CoA dehydrogenase	-
BJP78_RS14050	3032429..3033073	-	645	WP_084024233.1	class I SAM-dependent methyltransferase	-
BJP78_RS14055	3033349..3033753	+	405	WP_084024231.1	DUF732 domain-containing protein	-
BJP78_RS24500	3034449..3035600	-	1152	WP_158295305.1	hypothetical protein	-
BJP78_RS14070	3035687..3036028	+	342	WP_084024227.1	DUF2384 domain-containing protein	Antitoxin
BJP78_RS14075	3036025..3036585	+	561	WP_084024225.1	RES domain-containing protein	Toxin
BJP78_RS14080	3036643..3038097	-	1455	WP_137452194.1	hypothetical protein	-
BJP78_RS14085	3038087..3038428	-	342	WP_084024221.1	hypothetical protein	-
BJP78_RS14090	3038498..3039367	-	870	WP_099270689.1	hypothetical protein	-
BJP78_RS14095	3039771..3040307	+	537	WP_084024217.1	anti-sigma factor	-
BJP78_RS14100	3040596..3041423	-	828	Protein_2734	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (25-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-110)

Sequences

Toxin

Protein

• Length: 187 a.a.
• Molecular weight: 20306.78 Da
• Isoelectric Point: 4.6089

>T68527 WP_084024225.1 NZ_CP018014:3036025-3036585 [Mycobacterium avium subsp. hominissuis]
VSEALDEGLVQRIDARGTTEWSGTCYRYTGAHRDALSGEGARRFGGRWNPPLLFPAIYLADSAQACMVEVERVAQAASTT
AEKMLEATYRLHTIDVTDLAVLDLRTPDAREAVGLENDDIYGDDWSACQAVGHAAWFLHMQGVLVPAAGGVGVVVTAYEQ
RTRPGQLQLRQSVDLTPVLYQELRAT

Nucleotide

• Length: 561 bp

>T68527 NZ_CP018014:3036025-3036585 [Mycobacterium avium subsp. hominissuis]
GTGAGCGAAGCCCTCGATGAAGGGCTCGTCCAACGCATCGACGCACGCGGCACAACAGAGTGGTCGGGAACGTGCTACCG
CTATACCGGCGCGCATCGTGACGCCTTGTCCGGGGAGGGGGCACGCAGATTCGGAGGCAGGTGGAATCCACCCCTACTTT
TTCCGGCGATCTATCTTGCTGACTCCGCCCAGGCCTGCATGGTTGAGGTGGAACGGGTAGCGCAAGCGGCCTCAACGACC
GCAGAGAAGATGCTCGAGGCGACCTACCGACTGCACACCATCGATGTAACGGACCTGGCCGTTCTCGATCTGCGCACCCC
AGACGCCCGCGAAGCGGTAGGGCTCGAGAACGATGACATCTACGGCGATGACTGGTCAGCGTGCCAGGCGGTAGGGCACG
CAGCATGGTTCCTGCACATGCAAGGCGTCCTGGTGCCCGCGGCGGGCGGTGTCGGCGTAGTTGTCACCGCGTATGAACAA
CGAACCCGTCCAGGTCAACTACAGCTGCGACAAAGCGTCGATCTGACGCCTGTCCTTTACCAAGAACTCCGAGCCACCTA
A

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12474.31 Da
• Isoelectric Point: 4.8483

>AT68527 WP_084024227.1 NZ_CP018014:3035687-3036028 [Mycobacterium avium subsp. hominissuis]
MGVNALASTVSGAIERLGLTYEEVGEIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Nucleotide

• Length: 342 bp

>AT68527 NZ_CP018014:3035687-3036028 [Mycobacterium avium subsp. hominissuis]
ATGGGAGTAAACGCGCTCGCCTCGACGGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGCGAAAT
CGTCGATGCCTCCCCGCGCTCCGTGGCGCGATGGACCGCAGGTCAGGTAGTTCCTCAACGTCTCAACAAGCAACGACTAA
TCGAGCTGGCCTATGTCGCCGACGCCCTGGCGGAAGTGTTGCCGCGTGACCAGGCGAATGTGTGGATGTTTTCGCCGAAT
CGATTACTAGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAATACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA