Detailed information of TA system TA068525

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): unclassified/Polyketide_cyc2(toxin)
• Location: 877182..877835
• Replicon: chromosome
• Accession: NZ_CP018014
• Organism: Mycobacterium avium subsp. hominissuis strain OCU901s_S2_2s

Toxin (Protein)

• Gene name: novel[antitoxin]
• Uniprot ID: -
• Locus tag: BJP78_RS04455
• Protein ID: WP_003872880.1
• Coordinates: 877374..877835 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: novel[toxin]
• Uniprot ID: A0A808C2V3
• Locus tag: BJP78_RS04450
• Protein ID: WP_023869662.1
• Coordinates: 877182..877370 (+)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BJP78_RS04440	873164..874750	+	1587	WP_023869664.1	serine hydrolase	-
BJP78_RS04445	874747..877119	+	2373	WP_023869663.1	cation-translocating P-type ATPase	-
BJP78_RS04450	877182..877370	+	189	WP_023869662.1	antitoxin	Antitoxin
BJP78_RS04455	877374..877835	+	462	WP_003872880.1	SRPBCC family protein	Toxin
BJP78_RS04460	877904..878338	+	435	WP_023869661.1	hypothetical protein	-
BJP78_RS04465	878343..878819	-	477	WP_023869660.1	VOC family protein	-
BJP78_RS04470	879784..881367	+	1584	WP_003872878.1	DUF4185 domain-containing protein	-
BJP78_RS04475	881414..881800	+	387	WP_023869659.1	hypothetical protein	-
BJP78_RS04480	881835..882053	-	219	WP_023869658.1	hypothetical protein	-
BJP78_RS04485	882244..882818	-	575	Protein_872	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Polyketide cyclase/dehydrase (2-142)

Antitoxin

• Antitoxin Rv0909/MT0933 (4-51)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 16626.19 Da
• Isoelectric Point: 9.5654

>T68525 WP_003872880.1 NZ_CP018014:877374-877835 [Mycobacterium avium subsp. hominissuis]
VAKLSGSIDVPLPPEVAWQHASDLSRYKEWLTIHRVWRSTLPDQIDKGTVVESIVEVKGMLNRIKWTVVRYKPPEGMTLN
GDGVGGVKVKLMAKVQPKADGSVVSFDVHLGGPALFGPIGMIVAAALRGDIDQSLENFVTVFARSDPSTNGHR

Nucleotide

• Length: 462 bp

>T68525 NZ_CP018014:877374-877835 [Mycobacterium avium subsp. hominissuis]
GTGGCCAAGCTATCCGGATCCATCGATGTTCCGCTGCCGCCCGAGGTGGCCTGGCAGCATGCCTCCGACCTGTCCCGGTA
CAAGGAGTGGCTGACCATTCACCGGGTGTGGCGCAGCACCTTGCCCGACCAGATCGACAAGGGCACCGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAATGGACGGTGGTGCGCTACAAGCCACCGGAGGGCATGACGCTCAAC
GGCGACGGCGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGGTGCAGCCCAAGGCGGACGGTTCCGTCGTCAGCTTCGA
CGTGCACCTCGGCGGTCCGGCGCTGTTCGGGCCCATCGGCATGATCGTCGCGGCCGCGCTGCGCGGCGACATCGACCAGT
CGCTGGAGAACTTCGTCACGGTGTTCGCCCGATCGGATCCGAGCACCAACGGTCATCGCTGA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6729.36 Da
• Isoelectric Point: 4.4702

>AT68525 WP_023869662.1 NZ_CP018014:877182-877370 [Mycobacterium avium subsp. hominissuis]
MGFLDKAKDLLSQNADKVEIAIDKAGEFVDDKTQGKYSDTIHQVQEQAKKATGSTETGDQQG

Nucleotide

• Length: 189 bp

>AT68525 NZ_CP018014:877182-877370 [Mycobacterium avium subsp. hominissuis]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGTCGCAGAACGCCGACAAGGTCGAGATTGCCATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATCCACCAGGTGCAGGAGCAGGCCAAGAAGGCCACCGGCA
GCACCGAGACCGGCGACCAGCAGGGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A808C2V3